Conjugated Primary Antibodies
Rabbit (Oryctolagus cuniculus)
APC/Adenomatous Polyposis Coli
This is a highly specific antibody against APC/Adenomatous Polyposis Coli.
1ug per 1ul
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human APC
Gene ID Number
Human, Mouse, Rat
Cross-reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the antigen
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Purified by Protein A.
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
GS; DP2; DP3; BTPS2; DP2.5; PPP1R46; Adenomatous polyposis coli protein; Protein APC; Deleted in polyposis 2.5; APC
Anti-APC/Adenomatous Polyposis Coli
Immunoglobulin G (IgG)