Caspase-12 Substrate ATAD-AFC

  • Catalog number
    1117-1000
  • Price
    Please ask
  • Size
    1000 assays
  • Alternative_name
    Ac-ATAD-AFC, Caspase-12 Substrate, Fluorogenic
  • Description
    Ready-to-use fluorometric substrate for caspases that recognize the amino acid sequence ATAD. Caspase activity can be quantified by fluorescent detection of free AFC after cleaved from the peptide substrate ATAD-AFC at Ex/Em = 400/505 nm using a fluorometer or a fluorescence plate reader. Alternatively, a shift in fluorescence from blue to green upon cleavage can be visualized using a hand-held long-UV lamp. The ready-to-use caspase substrate provides an economic alternative for researchers who perform large amount of caspase assays. Cell Lysis Buffer (Cat.# 1067-100), 2X Reaction Buffer (Cat.# 1068-20), DTT (Cat.# 1201-1), and other reagents used for caspase activity assays are also available separately.
  • Structure Available
    No
  • Peptide sequence
    Ac-Ala-Thr-Ala-Asp-AFC
  • Salt Form
    No
  • Molecular Formula
    C₂₆H₃₀F₃N₅O₁₀
  • Molecular Weight
    629.54
  • Cell Permeable
    No
  • Purity
    >90% by HPLC
  • Handling
    Protect from light and moisture
  • Tag Line
    A caspase-12 substrate
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    12 months
  • SMILES
    N/A
  • InChi
    N/A
  • InChi Key
    N/A
  • MSDS Available
    Yes
  • Additional description
    Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
MeSH Data
  • Name
  • Concept
    Scope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
  • Tree numbers
    • E05.599.495
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