SR 3576, JNK3 kinase inhibitor
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Catalog number
SIH-513-5MG
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Price
Please ask
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Size
5 mg
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Stock availabilitIn Stock
In Stock
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CAS number
1164153-22-3
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Description
JNK3 kinase inhibitor
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Molecular weight
501,5 g/mol
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Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other name
SR3576, 3-(5-(3-m-Tolylureido)-1H-indazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide, 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C27H27N5O5
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Origin
Synthetic
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Purity pourcentage
≥98% (HPLC)
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Soluble in
Soluble to 100 mM in DMSO
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Physical appearance
Off White solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
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PubChem number
70702008
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Scientific context
SR 3576 is a highly potent and selective JNK3 inhibitor. SR 3576 is a pyrazolourea compound and is cell-permeable.
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Bibliography
1. Kamenecka T., et al. (2009) J. Biol. Chem. 284(19): 12853–12861.
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Release date
1-Oct-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of SR 3576 (SIH-513), a JNK3 kinase inhibitor. CAS #: 1164153-22-3. Molecular Formula: C27H27N5O5. Molecular Weight: 501.5 g/mol. Chemical structure of SR 3576, a JNK3 kinase inhibitor (SIH-513). CAS # 1164153-22-3. Molecular Formula: C27H27N5O5.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.005
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbol
MAPK10
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Short name
SR 3576, JNK3 kinase inhibitor
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Alternative name
SR 3576, JNK3 phosphorylation catalyst suppressor
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Gene info
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