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Target antigen
TRPV6
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human, rat Predicted to work with: mouse
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Analyses
WB
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Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human TRPV6(18-37aa KFCRWFQRRESWAQSRDEQN), different from the related rat sequence by one amino acid, and from the mouse sequence by two amino acids.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the TRPV6 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The TRPV6 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
TRPV6(Transient Receptor Potential Cation Channel Subfamily V Member 6), also known as ECAC2,CAT1 or CATL, a membrane calcium channel which is responsible for the first step in calcium absorption in the intestine. TRPV6 is a member of the Transient receptor potential(TRP) family of membrane proteins. Using FISH, Peng et al.(2000) mapped the TRPV6 gene to chromosome 7q33-q34. Peng et al.(2000) determined that TRPV6 mediates calcium uptake independent of sodium, chloride, and hydrogen; however, calcium influx was higher at alkaline rather than acidic pH. Functional analysis by Peng et al.(2001) indicated that TRPV5 mediates greater calcium uptake than TRPV6. They concluded that TRPV5 and TRPV6 are calcium-selective channels and share a common ancestral gene.
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Related articles
1. Peng, J.-B., Brown, E. M., Hediger, M. A. Structural conservation of the genes encoding CaT1, CaT2, and related cation channels. Genomics 76: 99-109, 2001. 2. Peng, J.-B., Chen, X.-Z., Berger, U. V., Weremowicz, S., Morton, C. C., Vassilev, P. M., Brown, E. M., Hediger, M. A. Human calcium transport protein CaT1. Biochem. Biophys. Res. Commun. 278: 326-332, 2000. 3. Peng, J.-B., Zhuang, L., Berger, U. V., Adam, R. M., Williams, B. J., Brown, E. M., Hediger, M. A., Freeman, M. R. CaT1 expression correlates with tumor grade in prostate cancer. Biochem. Biophys. Res. Commun. 282: 729-734, 2001.
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Gene Name
TRPV6
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Protein Name
Transient receptor potential cation channel subfamily V member 6
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Gene Full Name
transient receptor potential cation channel, subfamily V, member 6
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Synonyms
ABP/ZF antibody|ABPZF antibody|Alu binding protein with zinc finger domain antibody|Calcium channel CaT1 antibody|Calcium transport protein 1 antibody|CaT L antibody|CaT Like antibody|CaT-L antibody|CaT-like antibody|CaT1 antibody|ecac antibody|ECaC2 antibody|Epithelial apical membrane calcium transporter/channel CaT1 antibody|Epithelial calcium channel 2 antibody|Epithelial calcium channel antibody|HSA277909 antibody|LP6728 antibody|MGC162545 antibody|NUDC antibody|Transient receptor potential cation channel subfamily V member 6 antibody|TrpV6 antibody|TRPV6_HUMAN antibody|ZFAB antibody
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Uniprot ID
Q9H1D0
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
