Cytokeratin, Basic (Type II or HMW) Antibody

• Catalog number
  GEN438006
• Price
  Please ask
• Size
  100ug

• Also known as
  Cytokeratin
• Other names
  keratin, type II cytoskeletal 1; Keratin, type II cytoskeletal 1; keratin, type II cytoskeletal 1; CK-1; cytokeratin 1; cytokeratin-1; 67 kDa cytokeratin; hair alpha protein; type-II keratin Kb1; epidermolytic hyperkeratosis 1; keratin 1; 67 kDa cytokeratin; Cytokeratin-1; CK-1; Hair alpha protein; Keratin-1; K1; Type-II keratin Kb1
• Category
  Antibodies
• Subcategory
  Mnoclonal antibodies
• Gene name
  KRT1
• Gene name synonims
  KRT3; KRT4; KRT5; KRT6; KRT8
• Other gene names
  KRT1; KRT1; K1; CK1; EHK; EHK1; EPPK; KRT1A; NEPPK; KRTA; CK-1; K1
• Clonality
  Monoclonal
• Immunoglobulin isotype
  IgG1
• Clone
  AE-3
• Host organism
  Mouse (Mus musculus)
• Species reactivity
  Human (Homo sapiens), Monkey, Cow, Dog, Rabbit (Oryctolagus cuniculus), Mouse (Mus musculus), Rat (Rattus norvegicus), Chicken.; Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
• Specificity and cross reactivity
  This MAb recognizes basic (Type II or HMW) cytokeratins, which include 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8). Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. The acidic keratins have molecular weights (MW) of 56.5, 55, 51, 50, 50', 48, 46, 45, and 40kDa. MAb AE3 recognizes the 65-67, 64, 59, 58, 56, and 52kDa keratins of basic subfamily. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE1/AE3 is a broad spectrum anti pan-keratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
• Purification method
  N/A
• Form Appearance
  N/A
• Concentration
  N/A
• Storage and shipping
  Store the antibody at +4C. Temperature variations in the range of 1 to 7 degrees Celsius are tolerable. We recommend NOT to freeze the antibody. Antibody is stable for 24 months.
• Tested applications
  ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistology (IH)
• Properties
  If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Description
  Basic proteins pH>7 are often produced recombinant and shouldn’t be precipitated by formic acid buffer.
• French translation
  anticorps

• Gene target
  Cytokeratin   HMW  
• Gene symbol
  CFAP97, CSPG4
• Short name
  Cytokeratin, ( II HMW) Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  Anti-Cytokeratin, Basic (Type II or HMW)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:29276
• Gene
  CFAP97
• Long gene name
  cilia and flagella associated protein 97
• Synonyms gene
  • KIAA1430
• Synonyms gene name
  • KIAA1430
• Synonyms
  • DKFZp434F1728
  • hmw
• GenBank acession
  • AB037851
• Locus
  4q35.1
• Discovery year
  2004-04-21
• Entrez gene record
  57587
• Pubmed identfication
  • 10718198
  • 24554765
  • 26638075
• RefSeq identity
  • NM_020827
• Classification
  • Cilia and flagella associated
• VEGA ID
  OTTHUMG00000160468

Gene info

• Identity
  HGNC:2466
• Gene
  CSPG4
• Long gene name
  chondroitin sulfate proteoglycan 4
• Synonyms gene name
  • chondroitin sulfate proteoglycan 4 (melanoma-associated)
• Synonyms
  • MCSPG
  • MEL-CSPG
  • MSK16
  • NG2
  • MCSP
  • HMW-MAA
  • CSPG4A
• Synonyms name
  • melanoma-associated chondroitin sulfate proteoglycan
• GenBank acession
  • X96753
  • AY359468
• Locus
  15q24.2
• Discovery year
  1997-11-28
• Entrez gene record
  1464
• Pubmed identfication
  • 8790396
  • 16407841
• RefSeq identity
  • NM_001897
• Classification
  • Proteoglycans
• VEGA ID
  OTTHUMG00000142836

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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