RANK Antibody

• Catalog number
  R30453
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  RANK
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P
• Recommended dilutions
  Western blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the RANK antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This RANK antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q9Y6Q6
• Purity
  Antigen affinity
• Description
  Receptor Activator of Nuclear Factor K B, also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is also expressed on dendritic cells and facilitates immune signaling. RANKL (Receptor Activator for Nuclear Factor K B Ligand) is found on the surface of stromal cells, osteoblasts, and T cells. By analysis of somatic cell and radiation hybrid panels, Anderson et al.(1997) mapped the RANK gene to 18q22.1.
• Immunogen
  An amino acid sequence from the N-terminus of human RANK (QIAPPCTSEKHYEHLG) was used as the immunogen for this RANK antibody.
• Storage
  After reconstitution, the RANK antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  RANK  
• Gene symbol
  ANKFY1, TNFRSF11A
• Short name
  Anti-RANK
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to RANK
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:20763
• Gene
  ANKFY1
• Long gene name
  ankyrin repeat and FYVE domain containing 1
• Synonyms
  • ANKHZN
  • KIAA1255
  • ZFYVE14
  • BTBD23
  • RANK-5
• Synonyms name
  • rabankyrin-5
• GenBank acession
  • AB033081
• Locus
  17p13.2
• Discovery year
  2003-04-29
• Entrez gene record
  51479
• Pubmed identfication
  • 10940552
  • 17273843
• RefSeq identity
  • NM_016376
• Classification
  • Zinc fingers FYVE-type
  • BTB domain containing
  • Ankyrin repeat domain containing
• VEGA ID
  OTTHUMG00000177727

Gene info

• Identity
  HGNC:11908
• Gene
  TNFRSF11A
• Long gene name
  TNF receptor superfamily member 11a
• Synonyms gene
  • PDB2
  • LOH18CR1
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 11a, activator of NFKB
  • Paget disease of bone 2
  • loss of heterozygosity, 18, chromosomal region 1
  • tumor necrosis factor receptor superfamily, member 11a, NFKB activator
• Synonyms
  • RANK
  • CD265
  • FEO
  • ODFR
  • TRANCE-R
• Synonyms name
  • osteoclast differentiation factor receptor
  • receptor activator of nuclear factor kappa B
  • familial expansile osteolysis
  • TRANCE receptor
• GenBank acession
  • AF018253
• Locus
  18q21.33
• Discovery year
  1998-12-04
• Entrez gene record
  8792
• Pubmed identfication
  • 9367155
  • 10615125
• Classification
  • CD molecules
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000132779
• Locus Specific Databases
  • LRG_194

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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