DAB2 (Ser24) Antibody, ALEXA FLUOR 594
-
Catalog number
bs-11044R-A594
-
Price
Please ask
-
Size
100ul
-
-
Long name
DAB2 (Ser24) Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
-
Also known as
Anti-DAB2 Ser24 PAb ALEXA FLUOR 594
-
Category
Conjugated Primary Antibodies
-
Conjugated with
ALEXA FLUOR® 594
-
Host Organism
Rabbit (Oryctolagus cuniculus)
-
Target Antigen
DAB2 Ser24
-
Specificity
This is a highly specific antibody against DAB2 Ser24.
-
Modification
Phosphorylation
-
Modification Site
Ser24
-
Clonality
Polyclonal
-
Clone
Polyclonal antibody
-
Concentration
1ug per 1ul
-
Subcellular location
Cytoplasm
-
Source
KLH conjugated synthetic phosphopeptide derived from human DAB2 around the phosphorylation site of Ser24 [AP(p-S)KK]
-
Gene ID Number
1601
-
Swiss Prot
P98082
-
Tested applications
IF(IHC-P)
-
Recommended dilutions
IF(IHC-P)(1:50-200)
-
Crossreactivity
Human, Mouse, Rat
-
Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
-
Background of the antigen
Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containg non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling.
-
Purification
Purified by Protein A.
-
Storage conditions
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
-
Excitation emission
590nm/617nm
-
Synonyms
DOC2; DOC-2; Disabled homolog 2; Adaptor molecule disabled-2; Differentially expressed in ovarian carcinoma 2; Differentially-expressed protein 2; DAB2
-
Properties
For facs or microscopy Alexa 1 conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
Conjugation
Alexa Fluor, ALEXA FLUOR® 594
-
Conjugated
Alexa conjugate 1
-
French translation
anticorps
-
Gene target
-
Gene symbol
DAB2
-
Short name
Anti-DAB2 Ser24
-
Technique
Antibody, antibodies against human proteins, antibodies for
-
Isotype
Immunoglobulin G (IgG)
-
Label
ALEXA FLUOR 594
-
Alternative name
DAB2 (Ser24) Polyclonal Antibody, ALEXA FLUOR 594
-
Alternative technique
antibodies
-
Gene info
-
Identity
-
Gene
-
Long gene name
DAB adaptor protein 2
-
Synonyms gene name
- disabled (Drosophila) homolog 2 (mitogen-responsive phosphoprotein)
- disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
- Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
- DAB2, clathrin adaptor protein
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year
1998-07-29
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
VEGA ID
MeSH Data
-
Name
-
Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
Similar products