Dofetilide

• Catalog number
  B1189-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane
• Description
  Dofetilide is a class III antiarrhythmic agent and inhibits the rapid delayed rectifier K⁺current (IKr) with IC₅₀values of 31.5 nM in guinea pig cardiomyocytes. At higher doses it demonstrates pro-arrhythmic activity in cell models. Therefore, dofetilide has been cautiously used in the treatment of atrial fibrillation, the conversion of flutter to sinus rhythm and in the maintenance of sinus rhythm after conversion.
• CAS Number
  115256-11-6
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₉H₂₇N₃O₅S₂
• Molecular Weight
  441.56
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (25 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A class III antiarrhythmic agent
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD00869707
• PubChem CID
  71329
• PubChem CID Link
• SMILES
  CN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C
• InChi
  InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3
• InChi Key
  IXTMWRCNAAVVAI-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Dofetilide  
• Short name
  Dofetilide
• Alternative name
  Dofetilide

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