anti-Nicastrin Antibody

• Catalog number
  3983
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  Nicastrin Antibody: Nicastrin, in addition to presenilin, PEN2, and APH-1 forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-a-converting enzyme (TACE) and the b-site cleavage enzyme (BACE) protease families, gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease. Nicastrin is also thought to be involved in cell proliferation and signaling, especially in regards to activation of Notch receptors as loss of Nicastrin expression results in mouse embryonic lethality.
• Gene names
  Nicastrin Antibody: ATAG1874, KIAA0253, UNQ1874/PRO4317, Nicastrin
• Antibodie s label
  unlabelled serum
• Purity
  Nicastrin Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  Nicastrin antibody was made against a 17 amino acid synthetic peptide from near the carboxy terminus of human Nicastrin.
• Immuno application
  ELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
• Antibody advice
  Nicastrin antibody can be used for detection of Nicastrin by Western blot at 0.5 - 2 ug/mL. Antibody can also be used for immunohistochemistry starting at 5 ug/mL. For immunofluorescence start at 20 ug/mL.
• Suspention pH azide
  Nicastrin Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  Nicastrin antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human, Mouse, Rat
• Omim nr
  24638433
• Ncbi nr
  NP_056146
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  23385
• GENE symbol
  NCSTN
• Antigene name
  nicastrin
• Source
  Homo sapiens
• Protein nr
  Q92542
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Nicastrin  
• Gene symbol
  NCSTN, NCSTNP1, NCLN
• Short name
  anti-Nicastrin Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toNicastrin (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:17091
• Gene
  NCSTN
• Long gene name
  nicastrin
• Synonyms
  • KIAA0253
  • APH2
• GenBank acession
  • AF240468
• Locus
  1q23.2
• Discovery year
  2005-02-08
• Entrez gene record
  23385
• Pubmed identfication
  • 9039502
  • 10993067
• RefSeq identity
  • NM_015331
• VEGA ID
  OTTHUMG00000033110
• Locus Specific Databases
  • LRG_223

Gene info

• Identity
  HGNC:39606
• Gene
  NCSTNP1
• Long gene name
  nicastrin pseudogene 1
• Locus
  21q21.3
• Discovery year
  2011-03-17
• VEGA ID
  OTTHUMG00000078705

Gene info

• Identity
  HGNC:26923
• Gene
  NCLN
• Long gene name
  nicalin
• Synonyms gene name
  • nicalin homolog (zebrafish)
• Synonyms
  • NICALIN
  • NET59
• Synonyms name
  • nicastrin-like protein
• GenBank acession
  • BC025926
• Locus
  19p13.3
• Discovery year
  2004-11-26
• Entrez gene record
  56926
• Pubmed identfication
  • 11230166
  • 17261586
• RefSeq identity
  • NM_020170
• Classification
  • M28 metallopeptidases
• VEGA ID
  OTTHUMG00000180687

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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