anti-Nicastrin Antibody
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Catalog number3983
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PricePlease ask
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Size0.02 mg, 0.1 mg
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Gene infoNicastrin Antibody: Nicastrin, in addition to presenilin, PEN2, and APH-1 forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-a-converting enzyme (TACE) and the b-site cleavage enzyme (BACE) protease families, gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease. Nicastrin is also thought to be involved in cell proliferation and signaling, especially in regards to activation of Notch receptors as loss of Nicastrin expression results in mouse embryonic lethality.
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Gene namesNicastrin Antibody: ATAG1874, KIAA0253, UNQ1874/PRO4317, Nicastrin
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Antibodie s labelunlabelled serum
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PurityNicastrin Antibody is affinity chromatography purified via peptide column.
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Ab raised inRabbit
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TypePolyclonal
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ImmunoglobulinIgG
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AntigenNicastrin antibody was made against a 17 amino acid synthetic peptide from near the carboxy terminus of human Nicastrin.
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Immuno applicationELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
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Antibody adviceNicastrin antibody can be used for detection of Nicastrin by Western blot at 0.5 - 2 ug/mL. Antibody can also be used for immunohistochemistry starting at 5 ug/mL. For immunofluorescence start at 20 ug/mL.
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Suspention pH azideNicastrin Antibody is supplied in PBS containing 0.02% sodium azide.
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Keep atNicastrin antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Works withHuman, Mouse, Rat
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Omim nr24638433
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Ncbi nrNP_056146
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Vial with antibodyin solution
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Quantity per ml1 mg/mL
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NCBI GENE nr23385
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GENE symbolNCSTN
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Antigene namenicastrin
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SourceHomo sapiens
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Protein nrQ92542
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolNCSTN, NCSTNP1, NCLN
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Short nameanti-Nicastrin Antibody
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative nameAntibody toNicastrin (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namenicastrin
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Synonyms
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GenBank acession
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Locus
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Discovery year2005-02-08
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namenicastrin pseudogene 1
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Locus
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Discovery year2011-03-17
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namenicalin
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Synonyms gene name
- nicalin homolog (zebrafish)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2004-11-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- M28 metallopeptidases
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data