Jak3 (Tyr980 + Tyr981) Antibody, HRP Conjugated

• Catalog number
  bs-3208R-HRP
• Price
  Please ask
• Size
  0.1ml

• Long name
  Jak3 (Tyr980 + Tyr981) Antibody, HRP Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  HRP
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  Jak3 Tyr980 + Tyr981
• Specificity
  This is a highly specific antibody against Jak3 Tyr980 + Tyr981. These phosphorylation sites are homologous to Tyr976 + Tyr977 in Mouse and Rat.
• Modification
  Phosphorylation
• Modification site
  Tyr980 + Tyr981
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen_range
  971-990/1124
• Subcellular location
  Cytoplasm, Cell membrane
• Source
  KLH conjugated synthetic phosphopeptide derived from human Jak3 around the phosphorylation site of Tyr980/981
• Gene ID number
  3718
• Swiss Prot
  P52333
• Tested applications
  WB, IHC-P
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500)
• Crossreactivity
  Human, Mouse, Rat
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  N/A
• Synonyms
  JAKL; LJAK; JAK-3; L-JAK; JAK3_HUMAN; Tyrosine-protein kinase JAK3; Janus kinase 3; Leukocyte janus kinase; JAK3
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. HRP conjugates are often primary rabbit polyclonal antibodies couples to the enzyme horseradish peroxidase (HRP), found in the roots of horseradish. Also monoclonal HRP conjugates are often used for Western Blot.
• Additional conjugation
  HRP Conjugated
• French translation
  anticorps

• Gene target
  Jak3   Tyr980   Tyr981   Conjugated  
• Short name
  Anti-Jak3 Tyr980 + Tyr981
• Technique
  Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
• Isotype
  Immunoglobulin G (IgG)
• Label
  HRP
• Alternative name
  Anti-Jak3 Tyr980 + Tyr981 PAb HRP
• Alternative technique
  antibodies
• Alternative to gene target
  Janus kinase 3, JAK-3 and JAK3_HUMAN and JAKL and L-JAK and LJAK, JAK3 and IDBG-37201 and ENSG00000105639 and 3718, transferase activity, Plasma membranes, Jak3 and IDBG-166648 and ENSMUSG00000031805 and 16453, BT.44422 and IDBG-641863 and ENSBTAG00000020904 and 538276

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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