anti- RANKL antibody
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Catalog numberFNab07108
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PricePlease ask
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Size2X100μg
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Formliquid
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PurificationImmunogen affinity purified
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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BackgroundThis gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
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Immunogentumor necrosis factor (ligand) superfamily, member 11
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SynonymsCD254, hRANKL2, ODF, OPGL, OPTB2, Osteoprotegerin ligand, RANKL, sOdf, TNFSF11, TRANCE
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Calculated MW32 kDa
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Uniprot IDO14788
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SpecificityHuman, Mouse
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Tested ApplicationELISA, WB, IHC, IF
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Recommended dilutionWB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
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Image1Immunohistochemistry of paraffin-embedded human colon tissue slide using FNab07108( RANKL Antibody) at dilution of 1:100
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Image4COLO 320 cells were subjected to SDS PAGE followed by western blot with FNab07108( RANKL Antibody) at dilution of 1:1000
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
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PropertiesIf you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolTNFSF11
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Short nameanti- RANKL antibody
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TechniqueAntibody, anti, antibody to, antibodies against human proteins, antibodies for
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HostRabbit
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IsotypeIgG
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Alternative nameantibody to- RANKL (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameTNF superfamily member 11
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Synonyms gene name
- tumor necrosis factor (ligand) superfamily, member 11
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-12-04
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Pubmed identfication
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Classification
- Tumor necrosis factor superfamily
- CD molecules
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data