Category Conjugated Primary Antibodies
Host Organism Rabbit (Oryctolagus cuniculus)
Source This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human 5-HTR2A
Swiss Prot P28223
Specificity This is a highly specific antibody against 5-HTR2.
Immunogen range 80-130/471
Subcellular location Cytoplasm
Tested applications IF(IHC-P)
Clone Polyclonal antibody
Modification Site None
Synonyms HTR2; 5-HT2A; 5-hydroxytryptamine receptor 2A; 5-HT-2; 5-HT-2A; Serotonin receptor 2A; HTR2A
Purification Purified by Protein A.
Crossreactivity Human, Mouse, Rat
Gene ID Number 3356
Recommended dilutions IF(IHC-P)(1:50-200)
Background of the antigen G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
Concentration 1ug per 1ul
Target Antigen 5-HTR2
Storage conditions Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Cross-reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.