Epoxomicin
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Catalog number2190-50
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PricePlease ask
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Size50 ug
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Alternative_nameN-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl- 1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-L-threoninamide; BU-4061T
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DescriptionOriginally isolated from Actinomycetes strain based on its potent in vivo antitumor activity, Epoxomicin is a potent, cell-permeable, selective and irreversible proteasome inhibitor. More potent inhibitor of the chymotrypsin-like activity of the proteasome than Lactacystin (Cat. No. 1709-100). Blocks also trypsin-like and PGPH activities of the proteasome.
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CAS Number134381-21-8
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₈H₅₀N₄O₇
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Molecular Weight554.7
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Cell PermeableYes
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Purity≥95% by HPLC
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SolubilitiesDMSO (~ 10 mg/ml)
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HandlingProtect from air and moisture
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Tag LineA potent proteasome inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life24months
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MDL NumberMFCD03791061
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PubChem CID11226684
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SMILESCCC(C)C(C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)C1(CO1)C)NC(=O)C(C(C)CC)N(C)C(=O)C
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InChiInChI=1S/C28H50N4O7/c1-11-16(5)21(30-27(38)23(17(6)12-2)32(10)19(8)34)25(36)31-22(18(7)33)26(37)29-20(13-15(3)4)24(35)28(9)14-39-28/h15-18,20-23,33H,11-14H2,1-10H3,(H,29,37)(H,30,38)(H,31,36)/t16-,17-,18+,20-,21-,22-,23-,28+/m0/s1
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InChi KeyDOGIDQKFVLKMLQ-JTHVHQAWSA-N
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MSDS AvailableYes
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Gene target
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Short nameEpoxomicin
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Alternative nameEpoxomicin
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