Epoxomicin

  • Catalog number
    2190-50
  • Price
    Please ask
  • Size
    50 ug
  • Alternative_name
    N-​acetyl-​N-​methyl-​L-​isoleucyl-​L-​isoleucyl-​N-​[(1S)-​3-​methyl-​ 1-​[[(2R)-​2-​methyloxiranyl]carbonyl]butyl]-​L-​threoninamide; BU-4061T
  • Description
    Originally isolated from Actinomycetes strain based on its potent in vivo antitumor activity, Epoxomicin is a potent, cell-permeable, selective and irreversible proteasome inhibitor. More potent inhibitor of the chymotrypsin-like activity of the proteasome than Lactacystin (Cat. No. 1709-100). Blocks also trypsin-like and PGPH activities of the proteasome.
  • CAS Number
    134381-21-8
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₂₈H₅₀N₄O₇
  • Molecular Weight
    554.7
  • Cell Permeable
    Yes
  • Purity
    ≥95% by HPLC
  • Solubilities
    DMSO (~ 10 mg/ml)
  • Handling
    Protect from air and moisture
  • Tag Line
    A potent proteasome inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    24months
  • MDL Number
    MFCD03791061
  • PubChem CID
    11226684
  • SMILES
    CCC(C)C(C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)C1(CO1)C)NC(=O)C(C(C)CC)N(C)C(=O)C
  • InChi
    InChI=1S/C28H50N4O7/c1-11-16(5)21(30-27(38)23(17(6)12-2)32(10)19(8)34)25(36)31-22(18(7)33)26(37)29-20(13-15(3)4)24(35)28(9)14-39-28/h15-18,20-23,33H,11-14H2,1-10H3,(H,29,37)(H,30,38)(H,31,36)/t16-,17-,18+,20-,21-,22-,23-,28+/m0/s1
  • InChi Key
    DOGIDQKFVLKMLQ-JTHVHQAWSA-N
  • MSDS Available
    Yes
  • Gene target
  • Short name
    Epoxomicin
  • Alternative name
    Epoxomicin
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