A potent, specific inhibitor of nuclear export signal (NES)-dependent protein export from the nucleus. It alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1(XPO1), a protein required for nuclear export of proteins containing a nuclear export sequence . At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it stabilizes the expression of p53.
LMB; Elactocin; Mantuamycin; CI-940; CL-1957A; PD-114720; ATS 1287B
0.2 mg/ml (EtOH)
Is this a salt?
Is it cell-permeable?
≥99% by HPLC
Maximum time for storage
Protect from air and light
For cells, cell lines and tissues in culture till half confluency.
Leptomycin B for activation
Leptomycin B to measure cellular activation