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Leptomycin B for cell activation

Leptomycin B for cell activation is available 0 time from Biovision labs

Description A potent, specific inhibitor of nuclear export signal (NES)-dependent protein export from the nucleus. It alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1(XPO1), a protein required for nuclear export of proteins containing a nuclear export sequence . At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it stabilizes the expression of p53.
Peptide sequence N/A
CAS number 87081-35-4
Molecular weight 540.73
Category Biochemicals
Other name LMB; Elactocin; Mantuamycin; CI-940; CL-1957A; PD-114720; ATS 1287B
Molecular formula C₃₃H₄₈O₆
Physical appearance Liquid
Supplied with 0.2 mg/ml (EtOH)
Is this a salt? No
Is it cell-permeable? Yes
Purification ≥99% by HPLC
Reconstitute instructions N/A
Storage condition -20°C
Shipping condition gel pack
Maximum time for storage 24 months
Storage instructions Protect from air and light
Additional description For cells, cell lines and tissues in culture till half confluency.
Gene targetLeptomycin for activation
Short name Leptomycin B for activation
Technique activation
Alternative name Leptomycin B to measure cellular activation
Tissue cell
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Leptomycin B for cell activation -
EU:+32-(0)1-658-90-45 US:+1-(408)780-0908 [email protected]
  • Leptomycin
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  • activation
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