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anti-ROCK1 Antibody (Clone 12M03)

anti-ROCK1 Antibody (Clone 12M03) is available 1 time from Biovision labs

3545-100 | anti-ROCK1 Antibody (Clone 12M03) size: ROCK1 Antibody (Clone 12M03) | 439.86 USD

Catalog number 3545-100
Supplier Biovision
Price 439.86 USD
Size ROCK1 Antibody (Clone 12M03)
1. Gene info
Identity 10251
Gene ROCK1
Long gene name Rho associated coiled-coil containing protein kinase 1
Synonyms
  • p160ROCK
Locus 18q11.1
Discovery year 1997-10-10
Entrez gene record 6093
Pubmed identfication
  • 8617235
RefSeq identity
  • NM_005406
Classification
  • AGC family kinases
  • Pleckstrin homology domain containing
Havana BLAST/BLAT OTTHUMG00000131723
Product images
    #0#.jpeg
Target of this antibody: ROCK-1 (cleaved)
Alternative names of antibody target: ROCK1 , P160ROCK , MGC131603 , MGC43611 , p160ROCK , EC 2.7.11.1
Background information: ROCK-1 (Rho-associated coiled coil-containing protein kinase 1) has been found to be a new caspase-3 substrate. ROCK-1 consists of an amino-terminal kinase domain and an inhibitory cysteine/histidine-rich C-terminal domain. During apoptosis, ROCK-1 is cleaved by caspase-3 at the conserved DETD1113/G sequence and its C-terminal inhibitory domain is removed, resulting in deregulated and constitutive kinase activity. The caspase-3 mediated cleavage and activation of ROCK-1 induces phosphorylation of MLC and membrane blebbing, the early events in the execution phase of apoptosis.
Antibody host: Mouse
Clonality of antibody: Monoclonal
Isotype: Mouse IgG
Clone: 12M03
This antibody reacts with: Human
Immunogene sequence: Synthetic peptide corresponding to the caspase-3 cleavage site
Concentration of antibody: 0.5 mg/ml
Form of antibody: Liquid
Formulation of this antibody: 100 µg (0.5 mg/ml) Protein G purified mouse anti-human ROCK1 monoclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.
Purification method: Affinity purified
This antibody has been succesfully tested for use in following methods: Western blot
Recommended usage: Western blotting (1-4 µg/ml). However, the optimal conditions should be determined individually. Jurkat cell lysate treated with camptothecin (2 µM for 6-8 hours) can be used as a positive control. The antibody has been selected for its ability to recognize the cleaved ROCK-1 in Western blotting. It does not recognize the full length protein.
Storage information: Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions: gel pack
How to handle this antibody: The antibody solution should be gently mixed before use.
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation anticorps
Gene targetROCK1 12M03
Short name anti-ROCK1 Antibody (Clone 12M03)
Technique Antibody, anti
Alternative name antibody to-Rho-associated, coiled-coil containing protein kinase 1 (Antibody to) (clonality 12M03)
Alternative technique antibodies
Alternative to gene target Rho-associated, coiled-coil containing protein kinase 1, P160ROCK and ROCK-I, ROCK1 and IDBG-1371 and ENSG00000067900 and 6093, transferase activity, Plasma membranes, Rock1 and IDBG-128359 and ENSMUSG00000024290 and 19877, ROCK1 and IDBG-644080 and ENSBTAG00000008403 and 785911
Clone name 12M03
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  • ROCK1
  • 12M03
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