(R)-Bicalutamide

• Catalog number
  B2173-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  (2R)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
• Description
  R-Bicalutamide is a first-generation antiandrogen that inhibits androgen action by competitively binding to the androgen receptor (AR). With other anti-androgens, R-bicalutimide decreases levels of Bcl-2, Bcl-XL, caspase-3, and PARP, induces apoptosis, and inhibits cell growth of prostate cancer cells. In similar animal models, this compound decreases plasma PSA levels and suppresses tumor growth. Bicalutamide binds the androgen receptor in two sites, distorting coactivator binding and inhibiting transcription.
• CAS Number
  113299-40-4
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₈H₁₄F₄N₂O₄S
• Molecular Weight
  430.37
• Cell Permeable
  Yes
• Purity
  ≥98%
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  An androgen antagonist
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  56069
• PubChem CID Link
• SMILES
  CC(CS(=O)(=O)C1=CC=C(C=C1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O
• InChi
  InChI=1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)/t17-/m0/s1
• InChi Key
  LKJPYSCBVHEWIU-KRWDZBQOSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Bicalutamide  
• Short name
  (R)-Bicalutamide
• Alternative name
  (R)-Bicalutamide

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