Recombinant Human Syndecan-1 / SDC1 / CD138 Protein (His tag)

• Catalog number
  PKSH031123-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  CD138;SDC;SYND1;syndecan;Syndecan-1
• Activity
  NA
• Sequence
  Met 1-Glu 251
• Fusion tag
  C-His
• Accession
  NP_002988.3
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞92 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  25.6 kDa
• AP Mol Mass
  48-55 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.
• Technical data
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Syndecan-1   SDC1   CD138   Protein   His   tag  
• Gene symbol
  SDC1
• Short name
  Recombinant Syndecan-1 / SDC1 / CD138 Protein (His tag)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens Syndecan-1 / SDC1 / CD138 Protein (histidine detection labelled)
• Alternative technique
  rec

Gene info

• Identity
  HGNC:10658
• Gene
  SDC1
• Long gene name
  syndecan 1
• Synonyms gene
  • SDC
• Synonyms
  • CD138
  • syndecan
  • SYND1
• Synonyms name
  • syndecan proteoglycan 1
• GenBank acession
  • AJ551176
• Locus
  2p24.1
• Discovery year
  1991-03-18
• Entrez gene record
  6382
• RefSeq identity
  • NM_001006946
• Classification
  • Syndecans
  • CD molecules
• VEGA ID
  OTTHUMG00000090751

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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