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Antithrombin III

Antithrombin III is available 4 times from Biovision labs

7013-30T | Antithrombin III Antibody size: 30 µg | 159.24 USD


7013-100 | Antithrombin III Antibody size: 100 µg | 359.15 USD


7298-500 | Antithrombin III, Human Plasma size: 500 ug | 308.59 USD


7298-100 | Antithrombin III, Human Plasma size: 100 ug | 178.27 USD

Antibody Target Antithrombin III
Target Alternative Name SERPINC1
Antibody Type Polyclonal
Species Reactivities Human, Mouse, Rat
Immunogen Sequence Human antithrombin III (Cat# 7298)
Accession # P01008
Gene Id 462
Form Liquid
Purification Affinity purified rabbit IgG
Application Western blot
Positive Control Western blot: h serum, m muscle, rat kidney, recombinant protein
Application And Usages Western blot: 1-4 µg
Storage Condition -20°C
Shipping Condition gel pack
Shelf Life 12 months
Western Blot Verified Verified
Immunocytochemistry Verified Not Verified
Immunofluorescence Verified Not Verified
Immunoprecipitation Verified Not Verified
ELISA Verified Not Verified
ChIP Verified Not Verified
Dot Blot Verified Not Verified
Flow Cytometry Verified Not Verified
Synonyms SERPINC1
Alternative_names SERPINC1
Recombinant No
Source Human Plasma
Purity by SDS-PAGE ≥95%
Molecular Weight 58 kDa
Storage Temp. -20°C
Shipping Gel Pack
Physical form description Lyophilized from 50 mM Tris-HCl, pH 8.0, with 150 mM NaCl.
Reconstitution Instructions In water or aqueous buffer
Background Information SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors, and has been found to be a marker for disseminated intravascular coagulation (DIC) and to be of prognostic significance in septic patients. SerpinC1 synthesized in the liver is the principal plasma serpin of blood coagulation proteases and inhibits thrombin and other factors such as Xa by the formation of covalently linked complexes. Thus it is one of the most important coagulation inhibitors and the fundamental enzyme for the therapeutical action of heparin. In common with SerpinA5 and D1, the inhibitory activity of SerpinC1 undergoes a dramatic increase in the presence of heparin and other glycosaminoglycans. ATIII mediates the promotion of prostaglandin release, an inhibitor of leucocyte activation and downregulator of many proinflammatory cytokines. Antithrombin III exerts anti-inflammatory properties in addition to its anti-coagulative mechanisms. In animal models of sepsis, ATIII affected cytokine plasma concentrations with a decrease of pro-inflammatory cytokines. The deficiency or functional abnormality of ATIII may result in an increased risk of thromboembolic disease, such as deep vein thrombosis and pulmonary embolism. In addition, it has been reported that SerpinC1 can alter or influence inflammatory processes via inhibition of NF-κB activation or actin polymerization. Antithrombin III is found in normal serum at 15 mg per 100 ml. Found at higher levels in plasma than in serum because of complexing with thrombin during coagulation. Clinically, reduced levels are indicative of hypercoagulability.
Species Human
Alternative technique antibodies
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EU:+32-(0)1-658-90-45 US:+1-(408)780-0908 [email protected]
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