Anti-VEGF-A Humanized Antibody
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Catalog numberA2136-100
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PricePlease ask
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Size100 µg
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Antibody TargetVEGF-A
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Target Alternative NamerhuFab V2, Fab-12 variant Y0317, RhuFab, vascular endothelial growth factor A, VEGFA
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Antibody TypeMonoclonal
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Species ReactivitiesHuman
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Immunogen SequenceHuman VEGF-A
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AccessionDB01270
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AppearanceColorless liquid
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FormLiquid
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Concentration1 mg/ml
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FormulationIn PBS, pH 7.5
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PurificationProtein A purified
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ApplicationIn vitro
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Application And UsagesIn vitro studies
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DescriptionThe research-grade biosimilar antibody is a recombinant humanized IgG1 kappa monoclonal without an Fc fragment. This antibody binds to the receptor-binding site of vascular endothelial growth factor A (VEGF-A) and inhibits binding with its receptors (VEGFR1 and VEGFR2). This prevents VEGF-mediated proliferation and migration of endothelial cells and angiogenesis. The original drug received FDA approval in 2006 for the treatment of wet age-related macular degeneration. The drug has also been approved to treat macular edema following retinal vein occlusion, diabetic macular edema, and diabetic retinopathy.
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Storage Condition-80ºC
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Shipping ConditionGel Pack
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Shelf Life12 months
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UsageFor Research Use Only! Not to be used in humans.
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HandlingThe antibody solution should be gently mixed before use.
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Additional descriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolVEGFA, VEGFD, VEGFC, HLA-A, IGHV5-10-1, CIDEA, RPA1, CDC37P1, OR1Q1
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Short nameAnti-VEGF-A Humanized Antibody
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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IsotypeIgG1, kappa
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Alternative nameAntibody toVEGF-A Humanized (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namevascular endothelial growth factor A
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Synonyms gene
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Synonyms gene name
- vascular endothelial growth factor
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Synonyms
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GenBank acession
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Locus
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Discovery year1994-01-10
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- VEGF family
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namevascular endothelial growth factor D
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Synonyms gene
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Synonyms gene name
- c-fos induced growth factor (vascular endothelial growth factor D)
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Synonyms
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GenBank acession
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Locus
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Discovery year1997-03-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- VEGF family
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namevascular endothelial growth factor C
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1996-10-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- VEGF family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemajor histocompatibility complex, class I, A
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C1-set domain containing
- Histocompatibility complex
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin heavy variable 5-10-1
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Synonyms gene
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Synonyms gene name
- immunoglobulin heavy variable 5-A (provisional, gene/pseudogene)
- immunoglobulin heavy variable 5-A (provisional)
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-04
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin heavy locus at 14q32.33
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecell death inducing DFFA like effector a
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Synonyms gene name
- cell death-inducing DFFA-like effector a
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-07-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namereplication protein A1
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Synonyms gene name
- replication protein A1 (70kD)
- replication protein A1, 70kDa
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Synonyms
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GenBank acession
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Locus
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Discovery year1993-12-14
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Nucleotide excision repair
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecell division cycle 37 pseudogene 1
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Synonyms gene name
- cell division cycle 37 homolog (S. cerevisiae) pseudogene 1
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Synonyms
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Locus
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Discovery year2009-01-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameolfactory receptor family 1 subfamily Q member 1
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Synonyms gene
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Synonyms gene name
- olfactory receptor, family 1, subfamily Q, member 1
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Synonyms
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Locus
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Discovery year1999-12-09
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Entrez gene record
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Classification
- Olfactory receptors, family 1
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
