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anti-RASSF1A Antibody

anti-RASSF1A Antibody is available 1 time from Biovision labs

A1221-100 | anti-RASSF1A Antibody size: RASSF1A Antibody | 381.06 USD

Catalog number A1221-100
Supplier Biovision
Price 381.06 USD
Size RASSF1A Antibody
Product images
    #0#.jpegAnti-RASSF1A Antibody (C10)
Target of this antibody: RASSF1
Alternative names of antibody target: Ras association domain-containing protein 1, 123F2, NORE2A, RASSF1, RDA32, REH3P21
Background information: RASSF1A is one of the most epigenetically silenced gene in human cancers and an important negative regulator of NFkB activation and potential tumor suppressor. It is required for death receptor-dependent apoptosis. It also mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. RASSF1A inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles; no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.
Antibody host: Mouse
Clonality of antibody: Monoclonal
Isotype: Mouse IgM ĸ
Clone: C10
This antibody reacts with: Human, Mouse
Immunogene sequence: Full length protein
Form of antibody: Liquid
Formulation of this antibody: In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide
Purification method: Affinity purified
This antibody has been succesfully tested for use in following methods: WB, IH, IP
Recommended usage: WB- 1:50, IHC- 1:50, IP- 1.5 µg
Storage information: Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions: gel pack
How to handle this antibody: The antibody solution should be gently mixed before use
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation anticorps
Gene targetRASSF1A
Short name anti-RASSF1A Antibody
Technique Antibody, anti
Alternative name antibody to-RASSF1A (Antibody to)
Alternative technique antibodies
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anti-RASSF1A Antibody | Technique alternative | 01012195213
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