MLN8237
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Catalog number2718-5
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PricePlease ask
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Size5 mg
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Alternative_name4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy-benzoic acid; Alisertib
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DescriptionMLN8237 is a potent and selective inhibitor of Aurora kinase A (IC₅₀ =1.2 nM). It displays >200-fold higher selectivity for Aurora kinase A over Aurora kinase B. Displays antineoplastic activity.
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CAS Number1028486-01-2
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Structure AvailableY
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Salt FormNo
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Molecular FormulaC₂₇H₂₀ClFN₄O₄
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Molecular Weight518.9
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>40 mg/ml)
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HandlingProtect from air and light
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Tag LineA potent Aurora kinase A inhibitor
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Storage Condition-20°C
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Shipping ConditionGel pack
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Shelf Life36 months
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PubChem CID24771867
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SMILESCOC1=C(C(=CC=C1)F)C2=NCC3=CN=C(N=C3C4=C2C=C(C=C4)Cl)NC5=CC(=C(C=C5)C(=O)O)OC
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InChiInChI=1S/C27H20ClFN4O4/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2/h3-11,13H,12H2,1-2H3,(H,34,35)(H,31,32,33)
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InChi KeyZLHFILGSQDJULK-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short nameMLN8237
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Alternative nameMLN8237
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