Category Conjugated Primary Antibodies
Host Organism Rabbit (Oryctolagus cuniculus)
Source This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Gamma-glutamyltransferase 5 heavy chain
Specificity This is a highly specific antibody against GGT5 heavy chain.
Subcellular location Extracellular
Tested applications FCM, IF(IHC-P)
Clone Polyclonal antibody
Modification Site None
Synonyms Gamma glutamyl transpeptidase related enzyme; Gamma glutamyltranspeptidase 5; Gamma-glutamyl transpeptidase-related enzyme; Gamma-glutamyltransferase 5 heavy chain; Gamma-glutamyltransferase-like activity 1; Gamma-glutamyltranspeptidase 5; GGT 5; GGT REL; GGT-rel; GGT5; GGT5_HUMAN; DKFZP566O011; GGTLA1; Glutathione hydrolase 5; Leukotriene-C4 hydrolase; Gamma-glutamyltransferase 5 heavy chain.
Purification Purified by Protein A.
Crossreactivity Human, Mouse, Rat
Gene ID Number 2687
Recommended dilutions FCM(1:20-100), IF(IHC-P)(1:50-200)
Background of the antigen g-glutamyltranspeptidase (GGT) acts as a glutathionase and catalyzes the transfer of the glutamyl moiety of Glutathione to a variety of amino acids and dipeptide acceptors. This enzyme is located on the outer surface of the cell membrane and is widely distributed in mammalian tissues involved in absorption and secretion. In humans, hepatic GGT activity is elevated in some liver diseases. GGT1 is released into the bloodstream after liver damage and an elevated level of the enzyme may be a useful early sign of hepatocellular carcinoma. GGT5 converts Leukotriene C4 to Leukotriene D4; it does not, however, convert synthetic substrates that are commonly used to assay GGT. In human serum and tissues there is a marked heterogeneity in GGT, but this heterogeneity can be attributed to different glycosylation of the same peptide rather than to the products of different genes.
Concentration 1ug per 1ul
Target Antigen GGT5 heavy chain
Storage conditions Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Cross-reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.