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Mouse Anti Human PINK1 Monoclonal IgG1 Clone S4 15

Mouse Anti Human PINK1 Monoclonal IgG1 Clone S4 15 is available 19 times from Stressmark antibodies labs

SMC-450D-A655 | Mouse Anti-Human PINK1 Monoclonal IgG1, Clone S4-15 size: 100 µg | 447.12 USD

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SMC-450D-HRP | Mouse Anti-Human PINK1 Monoclonal IgG1, Clone S4-15 size: 100 µg | 433.57 USD

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SMC-450D-P594 | Mouse Anti-Human PINK1 Monoclonal IgG1, Clone S4-15 size: 100 µg | 455.03 USD

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SMC-450D-APC | Mouse Anti-Human PINK1 Monoclonal IgG1, Clone S4-15 size: 100 µg | 445.99 USD

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SMC-450D-A680 | Mouse Anti-Human PINK1 Monoclonal IgG1, Clone S4-15 size: 100 µg | 447.12 USD

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SMC-450D-A488 | Mouse Anti-Human PINK1 Monoclonal IgG1, Clone S4-15 size: 100 µg | 447.12 USD

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SMC-450D-PCP | Mouse Anti-Human PINK1 Monoclonal IgG1, Clone S4-15 size: 100 µg | 445.99 USD

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SMC-450D-FITC | Mouse Anti-Human PINK1 Monoclonal IgG1, Clone S4-15 size: 100 µg | 438.09 USD

Catalog number SMC-450D-FITC
Price 438.09 USD
Size 100 µg
Antibody's full description Mouse Anti-Human PINK1 Monoclonal IgG1 Antibody, Clone: S4-15: FITC
Net weight (g) 0.1
1. Gene info
Identity 14581
Gene PINK1
Long gene name PTEN induced kinase 1
Synonyms gene
  • PARK6
Synonyms gene name
  • Parkinson disease (autosomal recessive) 6
  • PTEN induced putative kinase 1
Synonyms
  • BRPK
GenBank acession
  • AB053323
Locus 1p36.12
Discovery year 2001-02-08
Entrez gene record 65018
Pubmed identfication
  • 24751536
  • 11494141
  • 15349860
  • 14607334
RefSeq identity
  • NM_032409
Classification
  • MicroRNA protein coding host genes
Havana BLAST/BLAT OTTHUMG00000002841
Locus Specific Databases
  • Global Variome shared LOVD
2. Gene info
Identity 9547
Gene PSMC1
Long gene name proteasome 26S subunit, ATPase 1
Synonyms gene name
  • proteasome (prosome, macropain) 26S subunit, ATPase, 1
Synonyms
  • S4
  • p56
GenBank acession
  • L02426
Locus 14q32.11
Discovery year 1995-11-27
Entrez gene record 5700
Pubmed identfication
  • 9473509
RefSeq identity
  • NM_002802
Classification
  • Proteasome
  • AAA ATPases
Havana BLAST/BLAT OTTHUMG00000171019
Product images
    #Mouse#.jpg#Human#.jpg

SMC-450D-A390 | Mouse Anti-Human PINK1 Monoclonal IgG1, Clone S4-15 size: 100 µg | 448.25 USD

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SMC-450D-A633 | Mouse Anti-Human PINK1 Monoclonal IgG1, Clone S4-15 size: 100 µg | 447.12 USD

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SMC-450D-RPE | Mouse Anti-Human PINK1 Monoclonal IgG1, Clone S4-15 size: 100 µg | 443.74 USD

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SMC-450D-STR | Mouse Anti-Human PINK1 Monoclonal IgG1, Clone S4-15 size: 100 µg | 444.87 USD

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SMC-450D | Mouse Anti-Human PINK1 Monoclonal IgG1, Clone S4-15 size: 100 µg | 392.93 USD

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SMC-450D-A565 | Mouse Anti-Human PINK1 Monoclonal IgG1, Clone S4-15 size: 100 µg | 447.12 USD

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SMC-450D-A700 | Mouse Anti-Human PINK1 Monoclonal IgG1, Clone S4-15 size: 100 µg | 447.12 USD

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SMC-450D-ALP | Mouse Anti-Human PINK1 Monoclonal IgG1, Clone S4-15 size: 100 µg | 440.35 USD

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SMC-450D-A594 | Mouse Anti-Human PINK1 Monoclonal IgG1, Clone S4-15 size: 100 µg | 447.12 USD

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SMC-450D-BI | Mouse Anti-Human PINK1 Monoclonal IgG1, Clone S4-15 size: 100 µg | 442.61 USD

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SMC-450S | Mouse Anti-Human PINK1 Monoclonal IgG1, Clone S4-15 size: 12 µg | 56.46 USD

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Clone S4-15
Immunogen Fusion protein amino acids 112-496 (cytoplasmic C-terminus) of human PINK1. 82% identical to rat and 81% identical to mouse. >30% identity with DMPK.
Antibody's category Monoclonal Antibodies
Antibody's other name Parkinson disease (autosomal recessive) 6 Antibody, EC 2.7.11.1 Antibody, PARK6 Antibody, serine/threonine-protein kinase PINK1 mitochondrial Antibody, PTEN-induced putative kinase protein 1 Antibody, protein kinase BRPK Antibody, BRPK Antibody, FLJ27236 Antibody, PTEN induced putative kinase 1 Antibody, Phosphatase and Tensin Homolog Antibody
Raised in Mouse
Antibody's target PINK1
Primary research fields Neuroscience, Cell Signaling, Post-translational Modifications, Phosphorylation, cardiovascular System, Heart
Brandname None
Antibodies' applications WB, IHC, ICC/IF
Antibody's reactivity Human, Mouse, Rat
Antibody's dilutions WB (1:1000); optimal dilutions for assays should be determined by the user.
Purity Protein G Purified
Antibody buffer for storage PBS pH 7.4, 50% glycerol, 0.1% sodium azide
Antibody's concentration 1 mg/ml
Antibody's specificity Detects ~50kDa.
Storage recommendations -20ºC
Shipping recommendations Blue Ice or 4ºC
Antibody certificate of analysis 1 µg/ml of SMC-450 was sufficient for detection of PINK1 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Antibody in cell Mitochondrion , Mitochondrion Outer Membrane , Cytoplasm
Tissue specificity See included datasheet or contact our support service
Scientific context PINK1 (PTEN induced putative kinase 1) is a mitochondrial serine/threonine kinase which maintains mitochondrial function/integrity, provides protection against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins, and is involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). PINK1 is synthesized as a 63 kD protein which undergoes proteolyt processing to generate at least two cleaved forms (55 kD and 42 kD). PINK1 and its substrates have been found in the cytosol as well as in different sub-mitochondrial compartments, and according to the recent reports; PINK1 may be targeted to OMM (outer mitochondrial membrane) with its kinase domain facing the cytosol, providing a possible explanation for the observed physical interaction with the cytosolic E3 ubiquitin ligase Parkin. Defective PINK1 may cause alterations in processing, stability, localization and activity as well as binding to substrates/interaction-partners which ultimately leads to differential effects on mitochondrial function and morphology. Mutations in PINK1 are linked to autosomal recessive early onset Parkinson's disease, and are associated with loss of protective function, mitochondrial dysfunction, aggregation of alpha-synuclein, as well as proteasome dysfunction.
Released date 26-Sep-2013
Tested applications To be tested
Tested reactivity To be tested
NCBI number NP_115785.1
Gene number 65018
Protein number Q9BXM7.1
Antibody's datasheet Contact our support service
Representative figure linkmore | details
Representative figure legend Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-PINK1 Monoclonal Antibody, Clone S4-15 (SMC-450). Tissue: Neuroblastoma cell line SK-N-BE. Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-PINK1 Monoclonal Antibody (SMC-450) at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000; 1:5000 for 60 min RT, 5 min RT. Localization: Cytoplasm. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) PINK1 Antibody (D) Composite. Western Blot analysis of Rat Brain showing detection of ~50 kDa PINK1 protein using Mouse Anti-PINK1 Monoclonal Antibody, Clone S4-15 (SMC-450). Lane 1: Molecular Weight Ladder. Lane 2: Rat Brain. Load: 15 µg. Block: 2% BSA and 2% Skim Milk in 1X TBST. Primary Antibody: Mouse Anti-PINK1 Monoclonal Antibody (SMC-450) at 1:200 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:1000 for 1 hour RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: ~50 kDa. Mouse Anti-PINK1 Antibody [S4-15] used in Immunocytochemistry/Immunofluorescence (ICC/IF) on Human Neuroblastoma cell line SK-N-BE (SMC-450) Mouse Anti-PINK1 Antibody [S4-15] used in Western Blot (WB) on Rat Brain (SMC-450)
Warning information Non-hazardous
Country of production Canada
Total weight (kg) 1.4
Stock availability In Stock
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Test StressMark antibodies supplies antibodies that are for research of human proteins.Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
Properties Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional isotype IgG1
About Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
Latin name Mus musculus
Gene targetPINK1 Monoclonal IgG1 S4-15
Short name Mouse Anti- PINK1 Monoclonal IgG1, Clone S4-15
Technique anti-Human, Mouse, anti
Host mouse
Isotype IgG1
Species Human
Alternative name Mouse antibody to-H. sapiens phosphatase and tensin homolog induced putative kinase 1 monoclonal IgG1, clonality S4-15
Alternative technique antibodies
Alternative to gene target PTEN induced putative kinase 1, PINK1 and IDBG-92922 and ENSG00000158828 and 65018, transferase activity, nuclei, Pink1 and IDBG-199773 and ENSMUSG00000028756 and 68943, PINK1 and IDBG-645657 and ENSBTAG00000006084 and 510683
Clone name S4-15
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  • PINK1
  • Monoclonal
  • IgG1
  • S4-15
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