TTP Antibody

• Catalog number
  3551-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  TTP
• Target Alternative Name
  G0/G1 switch regulatory protein 24, Growth factor-inducible, nuclear protein NUP475, Protein TIS11A, Zinc finger protein 36 homolog
• Antibody Type
  Polyclonal
• Species Reactivities
  Human, mouse, rat
• Immunogen Sequence
  Synthetic peptide at C-terminal
• Accession
  P26651
• Gene Id
  7538
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  0.5 mg/ml
• Formulation
  100 µg (0.5 mg/ml) of antibody in PBS, 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol, pH 7.2
• Purification
  Affinity purified
• Application
  Western blot
• Positive Control
  Western blot: Jurkat cell lysate
• Application And Usages
  Western blot: 1:200
• Description
  Tristetraprolin (TTP), also known as Nup475 and TIS11, is a zinc-binding protein encoded by the immediate-early response gene, Zfp-36. Stimulation of quiescent fibroblasts by mitogens, including platelet derived growth factor and fibroblast growth factor, results in the serine phosphorylation of TTP and the rapid redistribution of the protein from the nucleus to the cytoplasm. in vitro studies have demonstrated that TTP is phosphorylated by p42 MAP kinase, indicating that the activity of TTP may be regulated by the MAP kinase pathway in vivo. Knockout mice deficient in TTP develop autoimmunity, inflammatory arthritis and dermatitis. These conditions can be reversed by blocking the activity of the inflammatory mediator, tumor necrosis factor-alpha (TNF-α), suggesting that TTP may function to negatively regulate the expression of TNF-α.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TTP  
• Gene symbol
  ZFP36, ADAMTS13
• Short name
  TTP Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  TTP (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:12862
• Gene
  ZFP36
• Long gene name
  ZFP36 ring finger protein
• Synonyms gene name
  • zinc finger protein 36, C3H type, homolog (mouse)
• Synonyms
  • RNF162A
  • TIS11
  • G0S24
  • TTP
  • NUP475
• Synonyms name
  • tristetraprolin
• GenBank acession
  • M63625
• Locus
  19q13.2
• Discovery year
  1991-04-30
• Entrez gene record
  7538
• Pubmed identfication
  • 1699942
• Classification
  • Zinc fingers CCCH-type
• VEGA ID
  OTTHUMG00000182970

Gene info

• Identity
  HGNC:1366
• Gene
  ADAMTS13
• Long gene name
  ADAM metallopeptidase with thrombospondin type 1 motif 13
• Synonyms gene
  • C9orf8
• Synonyms gene name
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13
• Synonyms
  • VWFCP
  • TTP
  • vWF-CP
  • FLJ42993
  • MGC118899
  • MGC118900
  • DKFZp434C2322
• GenBank acession
  • AJ011374
• Locus
  9q34.2
• Discovery year
  1999-08-23
• Entrez gene record
  11093
• Pubmed identfication
  • 11557746
  • 11535495
• RefSeq identity
  • NM_139025
• Classification
  • ADAM metallopeptidases with thrombospondin type 1 motif
• VEGA ID
  OTTHUMG00000020876
• Locus Specific Databases
  • LRG_544

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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