FGF-21, murine recombinant
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Catalog number4067-1000
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PricePlease ask
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Size1 mg
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SynonymsFGF21, Fibroblast growth factor 21, FGFL
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Alternative_namesFGF21, Fibroblast growth factor 21, FGFL, UNQ3115/PRO10196
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DescriptionA heparin binding growth factor, stimulating the proliferation and activation of cells expressing FGFR
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RecombinantYes
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SourceE. coli
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Purity by SDS PAGE≥95%
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AssaySDS-PAGE
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Purity≥95%
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Molecular Weight20.1 kDa
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Storage Temp-20°C
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ShippingGel pack
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Shelf Life12 months
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AppearanceLyophilized protein
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Physical form descriptionLyophilized from filtered (0.4 mm) solution containing 20 mM Tris, pH 7.4 and 20 mM NaCl
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Reconstitution InstructionsCentrifuge the vial prior to opening. Reconstitute in sterile H₂O to a concentration ≥ 100 µg/ml. This solution can then be diluted into other aqueous buffers.
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Background InformationThe FGFs are a family of more than 20 small (~17–26 kDa) secreted peptides. The initial characterization of these proteins focused on their ability to stimulate fibroblast proliferation. FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs): FGFR-1, -2, -3, and -4, all with intrinsic tyrosine kinase activity and, except for FGFR-4, multiple splice isoforms, and FGFR-5, which lacks an intracellular kinase domain. There is growing evidence that FGFRs can be important for regulation of glucose and lipid homeostasis. FGFR-2 appears to be a key molecule during pancreatic development and FGFR-4 has been implicated in cholesterol metabolism and bile acid synthesis. FGF-21 is preferentially expressed in liver, but an exact knowledge of FGF-21 bioactivity and its mode of action have been lacking to date. FGF-21 is a potent activator of glucose uptake on adipocytes, protects animals from diet-induced obesity when overexpressed in transgenic mice, and lowers blood glucose and triglyceride levels when therapeutically administered to diabetic rodents. Fibroblast Growth Factor-21 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 183 amino acids including N-terminal Methionine and having a molecular mass of 20.1 kDa. The amino acid sequence of the recombinant mouse FGF21 is 100% homologous to the amino acid sequence of the mouse FGF21 without signal sequence. The FGF-21 is purified by proprietary chromatographic techniques.
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Amino acid sequenceMAYPIPDSSPLLQFGGQVRQRYLYTDDDQDTEAHLEIREDGTVVGAAHRSPESLLELKALKPGVIQILGVKASRFLCQQPDGALYGSPHFDPEACSFRELLLEDGYNVYQSEAHGLPLRLPQKDSPNQDATSWGPVRFLPMPGLLHEPQDQAGFLPPEPPDVGSSDPLSMVEPLQGRSPSYAS
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UsageFor Research Use Only! Not to be used in humans
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolFGF21, PIRC105, SNORD115-21, HTOR, FGF18, SNORD116-21, SNORD114-21, FGF17
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Short nameFGF-21, murine recombinant
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Alternative nameFGF-21, murine Rec.
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Alternative techniquerec
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Gene info
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Identity
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Gene
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Long gene namefibroblast growth factor 21
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GenBank acession
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Locus
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Discovery year1999-11-26
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Entrez gene record
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Pubmed identfication
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Classification
- Fibroblast growth factor family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namepiwi-interacting RNA cluster 105
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Locus
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Discovery year2009-11-05
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Entrez gene record
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Pubmed identfication
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Classification
- Piwi-interacting RNA clusters
Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, C/D box 115-21
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Synonyms
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GenBank acession
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Locus
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Discovery year2007-02-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNAs, C/D box
Gene info
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Identity
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Gene
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Long gene name5-hydroxytryptamine (serotonin) oxygenase regulator
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
Gene info
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Identity
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Gene
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Long gene namefibroblast growth factor 18
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-12-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Fibroblast growth factor family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, C/D box 116-21
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Synonyms
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GenBank acession
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Locus
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Discovery year2007-02-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNAs, C/D box
Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, C/D box 114-21
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Synonyms
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Locus
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Discovery year2006-09-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNAs, C/D box
Gene info
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Identity
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Gene
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Long gene namefibroblast growth factor 17
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-12-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Fibroblast growth factor family
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Methods or procedures used to obtain samples of URINE.
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Tree numbers
- E01.370.225.998.762
- E05.200.998.762
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Qualifiersethics, mortality, psychology, trends, veterinary, history, classification, economics, instrumentation, methods, nursing, standards, adverse effects, statistics & numerical data
