DDX58 (Thr170) Antibody, FITC Conjugated

• Catalog number
  bs-5300R-FITC
• Price
  Please ask
• Size
  0.1ml

• Long name
  DDX58 (Thr170) Polyclonal Antibody, FITC Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  FITC
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  DDX58 Thr170
• Specificity
  This is a highly specific antibody against DDX58 Thr170.
• Modification
  Phosphorylation
• Modification site
  Thr170
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human DDX58 around the phosphorylation site of Thr170
• Gene ID number
  23586
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the cytoplasmic helicase retinoic acid inducible gene protein 1 (RIG1/DDX58) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. Unlike TLR3 however, RIG1/DDX58 activates the kinases TBK1 and IKKe through the adaptor protein IPS1. These kinases then phosphorylate the transcription factors IRF3 and IRF7 which are essential for the expression of type-I interferons. RIG1/DDX58 is required for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  494nm/518nm
• Synonyms
  DEAD/H Asp-Glu-Ala-Asp/His box polypeptide RIG-I; DKFZp434J1111; DKFZp686N19181; FLJ13599; C330021E21; OTTHUMP00000045225; DEAD Asp-Glu-Ala-Asp box polypeptide 58; DEAD Asp Glu Ala Asp/His box polypeptide; DEAD box protein 58; Probable ATP dependent RNA helicase DDX58; Retinoic acid inducible gene 1 protein; RIG I; rig-I; RIG1; rigi; RNA helicase.
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS. When excited at 488 nanometers, FITC has a green emission that's usually collected at 530 nanometers, the FL1 detector of a FACSCalibur or FACScan. FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light. For fluorescent microscopy applications, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept. Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes.
• Additional conjugation
  Anti-FITC Antibody
• French translation
  anticorps

• Gene target
  DDX58   Thr170   Conjugated  
• Gene symbol
  DDX58
• Short name
  Anti-DDX58 Thr170
• Technique
  Antibody, FITC, antibodies against human proteins, antibodies for, antibody Conjugates, Fluorescein
• Isotype
  Immunoglobulin G (IgG)
• Label
  FITC
• Alternative name
  Anti-DDX58 Thr170 PAb FITC
• Alternative technique
  antibodies, fluorescine
• Alternative to gene target
  DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, RIG-I and RIGI and RLR-1, DDX58 and IDBG-55854 and ENSG00000107201 and 23586, hydrolase activity, Cell surfaces, Ddx58 and IDBG-135957 and ENSMUSG00000040296 and 230073, DDX58 and IDBG-629773 and ENSBTAG00000003366 and 504760

Gene info

• Identity
  HGNC:19102
• Gene
  DDX58
• Long gene name
  DExD/H-box helicase 58
• Synonyms gene name
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
• Synonyms
  • RIG-I
  • FLJ13599
  • DKFZp434J1111
  • RIG-1
  • RIG1
• Synonyms name
  • RNA helicase RIG-I
  • retinoic acid inducible gene I
• GenBank acession
  • AF038963
• Locus
  9p21.1
• Discovery year
  2004-05-10
• Entrez gene record
  23586
• Pubmed identfication
  • 21690088
• RefSeq identity
  • NM_014314
• Classification
  • DEAD-box helicases
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000019746

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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