Conjugated Primary Antibodies
Rabbit (Oryctolagus cuniculus)
This is a highly specific antibody against DDX58 Thr170.
1ug per 1ul
KLH conjugated synthetic phosphopeptide derived from human DDX58 around the phosphorylation site of Thr170
Gene ID number
Crossreactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the cytoplasmic helicase retinoic acid inducible gene protein 1 (RIG1/DDX58) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. Unlike TLR3 however, RIG1/DDX58 activates the kinases TBK1 and IKKe through the adaptor protein IPS1. These kinases then phosphorylate the transcription factors IRF3 and IRF7 which are essential for the expression of type-I interferons. RIG1/DDX58 is required for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus.
This antibody was purified via Protein A.
DEAD/H Asp-Glu-Ala-Asp/His box polypeptide RIG-I; DKFZp434J1111; DKFZp686N19181; FLJ13599; C330021E21; OTTHUMP00000045225; DEAD Asp-Glu-Ala-Asp box polypeptide 58; DEAD Asp Glu Ala Asp/His box polypeptide; DEAD box protein 58; Probable ATP dependent RNA helicase DDX58; Retinoic acid inducible gene 1 protein; RIG I; rig-I; RIG1; rigi; RNA helicase.
Immunoglobulin G (IgG)
Alternative to gene target
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, RIG-I and RIGI and RLR-1, DDX58 and IDBG-55854 and ENSG00000107201 and 23586, hydrolase activity, Cell surfaces, Ddx58 and IDBG-135957 and ENSMUSG00000040296 and 230073, DDX58 and IDBG-629773 and ENSBTAG00000003366 and 504760