Recombinant Murine Interleukin-27/p28 (IL-30)

• Catalog number
  4187-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  Interleukin-30, IL-30, IL-27/p28, p28, Interleukin-27, Interleukin-27/p28, IL-27, Interleukin-27 subunit α, IL-27 subunit α, IL27-A, Il27, Il27a, IL-27p28.
• Alternative_names
  Interleukin-30, IL-30, IL-27/p28, p28, Interleukin-27, Interleukin-27/p28, IL-27, Interleukin-27 subunit α, IL-27 subunit α, IL27-A, Il27, Il27a, IL-27p28.
• Description
  A regulator of B- and T-lymphocyte's activities
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥97%
• Assay
  SDS-PAGE
• Purity
  ≥97%
• Biological activity
  Measured by dose-dependent inhibition of TGF-β & Il-6-induced IL-17A expression in mouse CD4 splenocytes. 50 ng/ml of mouse p28 is capable of inhibiting >25% of Il-17A expression in this assay.
• Results
  50 ng/ml
• Molecular Weight
  23.7 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  Lyophilized from 10 mM NaP, pH 7.5
• Reconstitution Instructions
  Reconstitute in H₂O to a concentration of 0.1-0.5 mg/ml. The solution can then be diluted into other aqueous buffers
• Background Information
  The p28 subunit of IL-27 (IL-27/p28), also known as Interleukin-30 (IL-30), is a member of the IL-12 family of cytokines.  When combined with EBI3 (Epstein-Barr virus induced gene 3), p28 forms a heterodimer known as IL-27.  p28 is thought to be a pro-inflammatory cytokine inducing immuno-modulatory effects, but the details of these effects are currently unclear and research is focused on delineating its specific biological functions.  Recombinant mouse p28 is a non-glycosylated protein, containing 207 amino acids, with a molecular weight of 23.7 kDa.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Murine   Interleukin-27/p28   IL-30  
• Gene symbol
  IL27, SNORD114-30, SNORD116-30, SNORD115-30, IGKV2-30, RNU6-30P, IGHV3-30, IGLV3-30, IGHVII-30-21, IGHVII-30-1
• Short name
  Recombinant Murine Interleukin-27/p28 (IL-30)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  Rec. Murine Interleukin-27/p28 (Interleukin-30)
• Alternative technique
  rec

Gene info

• Identity
  HGNC:19157
• Gene
  IL27
• Long gene name
  interleukin 27
• Synonyms gene
  • IL30
• Synonyms gene name
  • interleukin 30
• Synonyms
  • IL-27
  • p28
  • IL27p28
  • IL-27A
  • IL27A
  • MGC71873
• GenBank acession
  • AY099296
• Locus
  16p12.1-p11.2
• Discovery year
  2002-11-04
• Entrez gene record
  246778
• Pubmed identfication
  • 12121660
• RefSeq identity
  • NM_145659
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000097023

Gene info

• Identity
  HGNC:33018
• Gene
  SNORD114-30
• Long gene name
  small nucleolar RNA, C/D box 114-30
• Synonyms
  • 14q(II-30)
• Locus
  14q32.31
• Discovery year
  2006-09-26
• Entrez gene record
  767611
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003223.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:42797
• Gene
  SNORD116-30
• Long gene name
  small nucleolar RNA, C/D box 116-30
• Synonyms
  • HBII-85-30
• Locus
  15q11.2
• Discovery year
  2011-08-22
• Entrez gene record
  100873856
• RefSeq identity
  • NR_047032
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:33049
• Gene
  SNORD115-30
• Long gene name
  small nucleolar RNA, C/D box 115-30
• Synonyms
  • HBII-52-30
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033804
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003345.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:5785
• Gene
  IGKV2-30
• Long gene name
  immunoglobulin kappa variable 2-30
• GenBank acession
  • X63403
• Locus
  2p11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28919
• RefSeq identity
  • NG_000834
• Classification
  • Immunoglobulin kappa locus at 2p11.2
• VEGA ID
  OTTHUMG00000151692

Gene info

• Identity
  HGNC:34274
• Gene
  RNU6-30P
• Long gene name
  RNA, U6 small nuclear 30, pseudogene
• Synonyms gene
  • RNU6-30
• Synonyms gene name
  • RNA, U6 small nuclear 30
• Locus
  Xq22.1
• Discovery year
  2008-06-10
• Entrez gene record
  100873747
• RefSeq identity
  • NR_046490

Gene info

• Identity
  HGNC:5591
• Gene
  IGHV3-30
• Long gene name
  immunoglobulin heavy variable 3-30
• GenBank acession
  • M83134
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28439
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000188332

Gene info

• Identity
  HGNC:5912
• Gene
  IGLV3-30
• Long gene name
  immunoglobulin lambda variable 3-30 (pseudogene)
• Synonyms gene name
  • immunoglobulin lambda variable 3-30
  • immunoglobulin lambda variable 3-30 pseudogene
• GenBank acession
  • Z73646
• Locus
  22q11.22
• Discovery year
  2000-05-08
• Entrez gene record
  28789
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000151182

Gene info

• Identity
  HGNC:52400
• Gene
  IGHVII-30-21
• Long gene name
  immunoglobulin heavy variable (II)-30-21 (pseudogene)
• Synonyms
  • IGHV(II)-30-21
• Locus
  14q32.33
• Discovery year
  2016-11-10
• Entrez gene record
  107548099
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33

Gene info

• Identity
  HGNC:5676
• Gene
  IGHVII-30-1
• Long gene name
  immunoglobulin heavy variable (II)-30-1 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable (II)-30-1
  • immunoglobulin heavy variable (II)-30-1 pseudogene
• Synonyms
  • IGHV(II)-30-1
• GenBank acession
  • AB019439
• Locus
  14q32.33
• Discovery year
  2000-04-17
• Entrez gene record
  28371
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152099

MeSH Data

• Name
  Urine Specimen Collection
• Concept
  Scope note: Methods or procedures used to obtain samples of URINE.
• Tree numbers
  • E01.370.225.998.762
  • E05.200.998.762
• Qualifiers
  ethics, mortality, psychology, trends, veterinary, history, classification, economics, instrumentation, methods, nursing, standards, adverse effects, statistics & numerical data

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