IMR-1 (Inhibitor of Mastermind Recruitment-1), is a small molecule inhibitor that disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex on chromatin, thereby attenuating Notch target gene transcription. Additionally, IMR-1 inhibits the growth of Notch-dependent cell lines and significantly abrogates the growth of patient-derived tumor xenografts.
(E)-Ethyl 2-(2-methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetate; Inhibitor of Mastermind Recruitment-1
Is this a salt?
Is it cell-permeable?
≥95% by HPLC
Maximum time for storage
Protect from air and light
For cells, cell lines and tissues in culture till half confluency.
IMR-1 for activation
IMR-1 to measure cellular activation