Bortezomib, Proteasome inhibitor

• Catalog number
  SIH-328-5MG
• Price
  Please ask
• Size
  5 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  179324-69-7
• Description
  Proteasome inhibitor
• Molecular weight
  384,2 g/mol
• Primary research fields
  Cancer, Apoptosis, Cancer Growth Inhibitors, Proteasome Inhibitors
• Other name
  B-[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid; [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid; Velcade; Radiciol; NSC 681239; DPBA; LDP 341; MG 341; mlN 341; NSC 681239; PS 314; PS 341; Radiciol; Velcade
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C19H25BN4O4
• Origin
  Synthetic
• Purity pourcentage
  >98%
• Soluble in
  Soluble in 50 mg/ml DMSO, 35 mg/ml Ethanol
• Physical appearance
  White Powder
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
• PubChem number
  387447
• Scientific context
  Potent and selective proteasome inhibitor (Ki=0.6 nM). Inhibits proliferation of a number of tumor cell lines (IC50=7 nM). Inhibits TNF synthesis and FGF-induced angiogenesis. Reversible. Cell permeable.
• Bibliography
  1. Adams J., et al. (1999) Cancer Res. 59: 2615. 2. Williams S., et al. (2003) Mol. Cancer Ther. 2: 835.
• Release date
  6-Jun-2012
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Bortezomib (SIH-328), a Proteasome inhibitor. CAS #: 179324-69-7. Molecular Formula: C19H25BN4O4. Molecular Weight: 384.2 g/mol. Chemical structure of Bortezomib, a Proteasome inhibitor (SIH-328). CAS # 179324-69-7. Molecular Formula: C19H25BN4O4.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.005
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Bortezomib   Proteasome   inhibitor  
• Short name
  Bortezomib, Proteasome inhibitor
• Alternative name
  Bortezomib, protein degradation aggregate suppressor

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