-
Stock availabilitIn Stock
In Stock
-
CAS number
120685-11-2
-
Description
Kinase inhibitor
-
Molecular weight
570,6 g/mol
-
Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
-
Other name
4’-N-Benzoyl-staurosporine, Midostaurin, CGP 41251
-
Product category
Small Molecules
-
Product type
Inhibitor
-
Chemical formula
C35H30N4O4
-
Origin
Synthetic
-
Purity pourcentage
≥98% (TLC)
-
Soluble in
Soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml) or 100% ethanol (2.5 mg/ml)
-
Physical appearance
White to off-white powder
-
Storage recommendations
-20ºC
-
Shipping recommendations
Shipped Ambient
-
Safety information
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
-
PubChem number
24202429
-
Scientific context
Midostaurin is a broad spectrum protein kinase inhibitor. It also shows inhibition of PKCα, PKCβ and PKCγ isoforms, Flk, and c-kit. Midostaurin displays antiproliferative characteristics and the ability to induce apoptosis.
-
Bibliography
1. Fabbro D., et al. (2000) Anti-Cancer Drug Design. 15(1): 17–28. 2. Odgerel, T., et al. (2008) Oncogene. 27(22): 3102–3110. 3. Bahlis, N.J., et al. (2005) Leukemia & Lymphoma. 46(6): 899–908.
-
Release date
1-Oct-2014
-
PubMed number
Refer to PubMed
-
Tested applications
To be tested
-
Tested reactivity
To be tested
-
-
Representative figure legend
Chemical structure of Midostaurin (SIH-468), a Protein kinase inhibitor (pan spec.). CAS #: 120685-11-2. Molecular Formula: C35H30N4O4. Molecular Weight: 570.6 g/mol. Chemical structure of Midostaurin, a Protein kinase inhibitor (pan spec.) (SIH-468). CAS # 120685-11-2. Molecular Formula: C35H30N4O4.
-
Warning information
Non-hazardous
-
Country of production
Canada
-
Total weight kg
0.25
-
Net weight g
0.005
-
-
Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
