b-AP15 (NSC-687852), DUB inhibitor

  • Catalog number
    SIH-339-25MG
  • Price
    Please ask
  • Size
    25 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    1009817-63-3
  • Description
    DUB inhibitor
  • Molecular weight
    419,4 g/mol
  • Primary research fields
    Cancer, Apoptosis
  • Other name
    (3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)-4-piperidinone
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C22H17N3O6
  • Origin
    Synthetic
  • Purity pourcentage
    >98%
  • Soluble in
    Soluble in 35 mg/ml DMSO
  • Physical appearance
    Pale Yellow Solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
  • PubChem number
    5351435
  • Scientific context
    Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. b-AP15 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo.
  • Bibliography
    1. D’Arcy P., et al. (2011) Nature Medicine 17: 1636.
  • Release date
    6-Jun-2012
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of b-AP15 (NSC-687852) (SIH-339), a DUB inhibitor. CAS #: 1009817-63-3. Molecular Formula: C22H17N3O6. Molecular Weight: 419.4 g/mol. Chemical structure of b-AP15 (NSC-687852), a DUB inhibitor (SIH-339). CAS # 1009817-63-3. Molecular Formula: C22H17N3O6.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.025
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
  • Short name
    b-AP15 (NSC-687852), DUB inhibitor
  • Alternative name
    b-AP15 (NSC-687852), DUB suppressor
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