MCP-1 (MCAF), rat recombinant

• Catalog number
  4224-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  Monocyte Chemotactic Protein-1, CCL2, MCAF
• Alternative_names
  Monocyte Chemotactic Protein-1, CCL2, MCAF, Monocyte chemoattractant protein 1, Monocyte secretory protein JE, Small-inducible cytokine A2
• Description
  Chemoattractant for monocytes and basophils
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥98%
• Assay
  SDS-PAGE
• Purity
  ≥98%
• Biological activity
  Determined by its ability to chemoattract human monocytes using a concentration range of 10-100 ng/ml.
• Results
  10-100 ng/ml.
• Molecular Weight
  14.0 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  Sterile filtered and then lyophilized with no additives. The protein may appear as a haze or film which is difficult to see at the bottom of the vial.
• Reconstitution Instructions
  Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other buffered solutions and stored at 4°C for 1 week or –20°C for future use.
• Background Information
  Macrophage/monocyte chemoattractant protein-1 (MCP-1) plays an important role in the inflammatory response of blood monocytes and tissue microphages. Recombinant rat MCP-1 is a 14.0 kDa protein containing 125 amino acid residues.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• About
  Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
• Latin name
  Rattus norvegicus
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  MCP-1   MCAF  
• Gene symbol
  CCL2, CAPG, CCL13, CCL8, SLC25A33, CD46, CCR2, CCL7, IGHVII-1-1, MIR1-1
• Short name
  MCP-1 (MCAF), recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Host
  Rat
• Species
  Rat, Rats
• Alternative name
  MCP-1 (MCAF), rat Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:10618
• Gene
  CCL2
• Long gene name
  C-C motif chemokine ligand 2
• Synonyms gene
  • SCYA2
• Synonyms gene name
  • small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
  • chemokine (C-C motif) ligand 2
• Synonyms
  • MCP1
  • MCP-1
  • MCAF
  • SMC-CF
  • GDCF-2
  • HC11
  • MGC9434
• Synonyms name
  • monocyte chemotactic protein 1, homologous to mouse Sig-je
  • monocyte chemoattractant protein-1
  • monocyte chemotactic and activating factor
  • monocyte secretory protein JE
  • small inducible cytokine subfamily A (Cys-Cys), member 2
• GenBank acession
  • BC009716
• Locus
  17q12
• Discovery year
  1990-07-05
• Entrez gene record
  6347
• Pubmed identfication
  • 2004761
• RefSeq identity
  • NM_002982
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000132887

Gene info

• Identity
  HGNC:1474
• Gene
  CAPG
• Long gene name
  capping actin protein, gelsolin like
• Synonyms gene
  • AFCP
• Synonyms gene name
  • capping protein (actin filament), gelsolin-like
• Synonyms
  • MCP
• Synonyms name
  • macrophage capping protein
• GenBank acession
  • M94345
• Locus
  2p11.2
• Discovery year
  1993-12-14
• Entrez gene record
  822
• Pubmed identfication
  • 1322908
  • 12754261
• RefSeq identity
  • NM_001747
• Classification
  • Gelsolin/villins
• VEGA ID
  OTTHUMG00000130183

Gene info

• Identity
  HGNC:10611
• Gene
  CCL13
• Long gene name
  C-C motif chemokine ligand 13
• Synonyms gene
  • SCYA13
• Synonyms gene name
  • small inducible cytokine subfamily A (Cys-Cys), member 13
  • chemokine (C-C motif) ligand 13
• Synonyms
  • MCP-4
  • NCC-1
  • SCYL1
  • CKb10
  • MGC17134
• GenBank acession
  • AJ001634
• Locus
  17q12
• Discovery year
  1997-02-11
• Entrez gene record
  6357
• Pubmed identfication
  • 8661057
• RefSeq identity
  • NM_005408
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000132890

Gene info

• Identity
  HGNC:10635
• Gene
  CCL8
• Long gene name
  C-C motif chemokine ligand 8
• Synonyms gene
  • SCYA8
• Synonyms gene name
  • small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2)
  • chemokine (C-C motif) ligand 8
• Synonyms
  • MCP-2
  • HC14
• GenBank acession
  • X99886
• Locus
  17q12
• Discovery year
  1996-11-14
• Entrez gene record
  6355
• Pubmed identfication
  • 9119400
• RefSeq identity
  • NM_005623
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000132883

Gene info

• Identity
  HGNC:29681
• Gene
  SLC25A33
• Long gene name
  solute carrier family 25 member 33
• Synonyms gene name
  • solute carrier family 25, member 33
  • solute carrier family 25 (pyrimidine nucleotide carrier), member 33
• Synonyms
  • MGC4399
  • BMSC-MCP
  • PNC1
• GenBank acession
  • AF495714
• Locus
  1p36.22
• Discovery year
  2006-09-21
• Entrez gene record
  84275
• Pubmed identfication
  • 14715278
  • 16949250
• RefSeq identity
  • NM_032315
• Classification
  • Solute carriers
• VEGA ID
  OTTHUMG00000001322

Gene info

• Identity
  HGNC:6953
• Gene
  CD46
• Long gene name
  CD46 molecule
• Synonyms gene
  • MIC10
  • MCP
• Synonyms gene name
  • antigen identified by monoclonal antibody TRA-2-10
  • membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
  • CD46 antigen, complement regulatory protein
  • CD46 molecule, complement regulatory protein
• Synonyms
  • TRA2.10
  • MGC26544
  • TLX
• GenBank acession
  • BC030594
• Locus
  1q32.2
• Discovery year
  1988-08-31
• Entrez gene record
  4179
• Pubmed identfication
  • 7929741
• RefSeq identity
  • NM_172361
• Classification
  • Sushi domain containing
  • Complement system regulators and receptors
  • CD molecules
• VEGA ID
  OTTHUMG00000036397
• Locus Specific Databases
  • LRG_155

Gene info

• Identity
  HGNC:1603
• Gene
  CCR2
• Long gene name
  C-C motif chemokine receptor 2
• Synonyms gene
  • CMKBR2
• Synonyms gene name
  • chemokine (C-C motif) receptor 2
• Synonyms
  • CC-CKR-2
  • CKR2
  • MCP-1-R
  • CD192
  • FLJ78302
• Locus
  3p21.31
• Discovery year
  1995-05-30
• Entrez gene record
  729230
• Pubmed identfication
  • 8146186
• RefSeq identity
  • NM_000647
• Classification
  • C-C motif chemokine receptors
  • CD molecules
• VEGA ID
  OTTHUMG00000156466

Gene info

• Identity
  HGNC:10634
• Gene
  CCL7
• Long gene name
  C-C motif chemokine ligand 7
• Synonyms gene
  • SCYA6
  • SCYA7
• Synonyms gene name
  • small inducible cytokine A7 (monocyte chemotactic protein 3)
  • chemokine (C-C motif) ligand 7
• Synonyms
  • MCP-3
  • NC28
  • FIC
  • MARC
  • MCP3
• Synonyms name
  • monocyte chemoattractant protein 3
  • monocyte chemotactic protein 3
• GenBank acession
  • AF043338
• Locus
  17q12
• Discovery year
  1993-11-04
• Entrez gene record
  6354
• Pubmed identfication
  • 8461011
• RefSeq identity
  • NM_006273
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000132889

Gene info

• Identity
  HGNC:5670
• Gene
  IGHVII-1-1
• Long gene name
  immunoglobulin heavy variable (II)-1-1 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable (II)-1-1
  • immunoglobulin heavy variable (II)-1-1 pseudogene
• Synonyms
  • IGHV(II)-1-1
• GenBank acession
  • AB019441
• Locus
  14q32.33
• Discovery year
  2000-04-17
• Entrez gene record
  28377
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152325

Gene info

• Identity
  HGNC:31499
• Gene
  MIR1-1
• Long gene name
  microRNA 1-1
• Synonyms gene
  • MIRN1-1
• Synonyms
  • hsa-mir-1-1
• Locus
  20q13.33
• Discovery year
  2004-04-23
• Entrez gene record
  406904
• RefSeq identity
  • NR_029780
• Classification
  • MicroRNA MIR1/206 family

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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