Other name TIM4, TIMD4, T Cell Immunoglobulin and Mucin Domain-containing Protein 4, T Cell Membrane Protein 4
Aa sequence N/A
NCBI number Q96H15
Source CHO cells
NCBI gene TIMD4
Storage condition -20°C
Level of endotoxin<0.06 EU/μg
Binding ability N/A
Gene source Human
Tested applications SDS-PAGE, N/A
Notes For Research Use Only! Not to be used in humans
Tested activity Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.
Background The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-4 (T cell; immunoglobulin; Mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIM-4 is exclusively expressed on antigen-presenting cells, where it mediates phagocytosis of apoptotic cells and plays an important role in maintaining tolerance. TIM-4 binds specifically to TIM-1 which is also the cellular receptor for the hepatitis A virus, and has been implicated in the development of asthma. Among hematopoietic cells, TIM-1 is expressed on activated B and T cells, preferentially in the Th2 subset of CD4+ T cells. The interaction of TIM-4 with TIM-1 induces costimulatory and hyperproliferative signals in T cells.
Before use Centrifuge the vial prior to opening.
Shipping under Gel pack
NCBI gene number 91937
Physical properties Lyophilized from 0.2 μm-filtered solution in PBS
Biological activity Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.
Physical appearance Lyophilized
Synonym TIM4; TIMD4, T Cell Immunoglobulin and Mucin Domain-containing Protein 4, T Cell Membrane Protein 4
How to reconstitute Reconstitute with 100 µl sterile water.
Properties Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional source Recombinants or rec. proteins