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Synonyms
Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, High molecular weight Kininogen, Williams-Fitzgerald-Flaujeac factor, BDK, KNG, Kininogen-1 heavy chain, T-kinin, Bradykinin, Lysyl-bradykinin, Kininogen-1 light chain, Low molecular weight growth-promoting factor
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Alternative_names
Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, High molecular weight Kininogen, Williams-Fitzgerald-Flaujeac factor, BDK, KNG, Kininogen-1 heavy chain, T-kinin, Bradykinin, Lysyl-bradykinin, Kininogen-1 light chain, Low molecular weight growth-promoting factor
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Description
A major extra-cellular cysteine proteinase inhibitor
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Recombinant
No
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Source
Human Plasma
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Purity by SDS PAGE
≥95%
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Assay
SDS-PAGE
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Molecular Weight
65 kDa
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Storage Temp
-20°C
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Shipping
Gel Pack
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Shelf Life
12 months
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Appearance
Lyophilized
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Physical form description
Lyophilized from 10 mM Na acetate, pH 5.5 with 200 mM NaCI
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Reconstitution Instructions
In water or aqueous buffer
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Background Information
LMW Kininogen is involved in blood pressure regulation since it is an endogenous protein substrate for tissue kallikrein. Proteolytic cleavage by kallikrein releases vasoactive bradykinin from LMW kininogen. In addition, LMW kininogen, like HMW kininogen, is a major extracellular cysteine protease inhibitor.
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Handling
Centrifuge the vial prior to opening.
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Usage
For Research Use Only! Not to be used in humans
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
