Caspase-3 Inhibitor Q-DEVD-OPh
-
Catalog number
1175-1
-
Price
Please ask
-
Size
1 mg
-
-
Alternative_name
Q-DEVD-Oph, Q-Asp-Glu-Val-Asp-Oph
-
Description
A second-generation capase-3 inhibitor that is potent, cell permeable, irreversible and nontoxic.
-
Structure Available
Yes
-
Peptide sequence
Quinolyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-OPh
-
Salt Form
No
-
Molecular Formula
C₃₈H₄₃F₂N₅O₁₂
-
Molecular Weight
799.77
-
Cell Permeable
Yes
-
Purity
>90% by HPLC
-
Solubilities
DMSO
-
Handling
Protect from moisture
-
Tag Line
A caspase-3 inhibitor
-
Storage Condition
-20°C
-
Shipping Condition
gel pack
-
Shelf Life
12 months
-
PubChem CID
44135278
-
-
SMILES
CC(C)C(C(=O)NC(CC(=O)OC)C(=O)COC1=C(C=CC=C1F)F)NC(=O)C(CCC(=O)OC)NC(=O)C(CC(=O)OC)NC(=O)C2=NC3=CC=CC=C3C=C2
-
InChi
InChI=1S/C38H43F2N5O12/c1-20(2)33(38(53)43-27(17-31(48)55-4)29(46)19-57-34-22(39)10-8-11-23(34)40)45-36(51)26(15-16-30(47)54-3)42-37(52)28(18-32(49)56-5)44-35(50)25-14-13-21-9-6-7-12-24(21)41-25/h6-14,20,26-28,33H,15-19H2,1-5H3,(H,42,52)(H,43,53)(H,44,50)(H,45,51)
-
InChi Key
BGPCNOMCMSKHOV-UHFFFAOYSA-N
-
-
MSDS Available
Yes
-
Additional description
Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways. Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
-
Gene target
-
Gene symbol
GNAQ, CENPQ, H2AC20, H2AC18, SYNCRIP, H2BC21
-
Short name
Caspase-3 Inhibitor Q-DEVD-OPh
-
Alternative name
caspase-3 suppressor Q-DEVD-OPh
-
Gene info
Gene info
-
Identity
-
Gene
-
Long gene name
centromere protein Q
-
Synonyms gene
-
Synonyms gene name
- chromosome 6 open reading frame 139
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year
2003-06-09
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Constitutive centromere associated network
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene name
H2A clustered histone 20
-
Synonyms gene
-
Synonyms gene name
- H2A histone family, member Q
- histone 2, H2ac
- histone cluster 2, H2ac
- histone cluster 2 H2A family member c
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year
1998-08-27
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene name
H2A clustered histone 18
-
Synonyms gene
-
Synonyms gene name
- H2A histone family, member O
- histone 2, H2aa
- histone 2, H2aa3
- histone cluster 2, H2aa3
- histone cluster 2 H2A family member a3
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year
1998-09-07
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
-
VEGA ID
Gene info
Gene info
-
Identity
-
Gene
-
Long gene name
H2B clustered histone 21
-
Synonyms gene
-
Synonyms gene name
- H2B histone family, member Q
- histone 2, H2be
- histone cluster 2, H2be
- histone cluster 2 H2B family member e
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year
1998-08-27
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
-
VEGA ID
MeSH Data
-
Name
-
Concept
Scope note:
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
-
Tree numbers
Similar products
