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Also known as
LSD1/AOF2
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Other names
lysine-specific histone demethylase 1A isoform a; Lysine-specific histone demethylase 1A; lysine-specific histone demethylase 1A; lysine (K)-specific demethylase 1; BRAF35-HDAC complex protein BHC110; amine oxidase (flavin containing) domain 2; FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit; flavin-containing amine oxidase domain-containing protein 2; lysine (K)-specific demethylase 1A; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2
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Category
Antibodies
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Subcategory
Mnoclonal antibodies
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Gene name
LSD1/AOF2
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Gene name synonims
N/A
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Other gene names
KDM1A; KDM1A; AOF2; KDM1; LSD1; BHC110; AOF2; KDM1; KIAA0601; LSD1
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Clonality
Monoclonal
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Immunoglobulin isotype
N/A
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Clone
1B2E5
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Host organism
Mouse (Mus musculus)
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Species reactivity
Human (Homo sapiens), Mouse (Mus musculus), Monkey; Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
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Specificity and cross reactivity
N/A; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
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Purification method
N/A
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Form Appearance
Ascitic fluid containing 0.03% sodium azide.
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Concentration
0.1mg/0.1ml
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Storage and shipping
Store the antibody at +4 degrees Celsius., for long term storage, store the antibody should be stored at -20 degrees Celsius.
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Tested applications
Western Blot (WB), Immunofluoresence (IF), ELISA (EIA)
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Properties
If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Gene
Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, was belonged to the superfamily of the Flavin adenine dinucleotide (FAD)-dependent amine oxidases. LSD1 specifically demethylates mono- or dimethylated dimethylated histone H3 lysine4 (H3K4) and H3 lysine 9 (H3K9) via a redox process. Recently evidences showed that LSD1 played an important role in a broad spectrum of biological processes, including cell proliferation, adipogenesis, spermatogenesis, chromosome segregation and embryonic development. Furthermore, LSD1 also could promote progress of tumor by inhibiting the tumor suppressor activity of p53. To date, as a potential drug for discovering anti-tumor drugs, the medical significance of LSD1 inhibitors have been greatly appreciated. Here, we reviewed the remarkable progress being made in understanding of LSD1, mainly on its structure, basic function and medical application in tumor therapy.
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French translation
anticorps
