anti- AMBRA1 antibody

• Catalog number
  FNab00356
• Price
  Please ask
• Size
  2X100μg

• Form
  liquid
• Purification
  Immunogen affinity purified
• Purity
  ≥95% as determined by SDS-PAGE
• Storage
  PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
• Background
  WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. AMBRA1 (Activating molecule in BECN1-regulated autophagy protein 1), also known as WDR94 or KIAA1736, is a 1, 298 amino acid protein that contains three WD repeats. Localized to cytoplasmic vesicles, AMBRA1 functions to control protein turnover, cell proliferation and cell survival during neuronal development, thereby playing an important role in autophagy and the development of the nervous system. Multiple isoforms of AMBRA1 exist due to alternative spicing events.
• Immunogen
  autophagy/beclin-1 regulator 1
• Synonyms
  AMBRA1, autophagy/beclin 1 regulator 1, FLJ20294, KIAA1736, WDR94
• Calculated MW
  Refer to Figures
• Uniprot ID
  Q9C0C7
• Specificity
  Human, Mouse, Rat
• Tested Application
  ELISA, IHC, WB
• Recommended dilution
  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
• Image1
  Immunohistochemistry of paraffin-embedded human liver cancer using FNab00356(AMBRA1 antibody) at dilution of 1:50
• Image4
  mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab00356(AMBRA1 antibody) at dilution of 1:1000
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Properties
  If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  AMBRA1  
• Gene symbol
  AMBRA1
• Short name
  anti- AMBRA1 antibody
• Technique
  Antibody, anti, antibody to, antibodies against human proteins, antibodies for
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  antibody to- AMBRA1 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:25990
• Gene
  AMBRA1
• Long gene name
  autophagy and beclin 1 regulator 1
• Synonyms gene name
  • autophagy/beclin-1 regulator 1
• Synonyms
  • FLJ20294
  • KIAA1736
  • WDR94
  • DCAF3
• Synonyms name
  • WD repeat domain 94
  • DDB1 and CUL4 associated factor 3
• GenBank acession
  • AB051523
• Locus
  11p11.2
• Discovery year
  2008-02-01
• Entrez gene record
  55626
• Pubmed identfication
  • 17622796
  • 17603510
  • 17589504
• RefSeq identity
  • NM_017749
• Classification
  • DDB1 and CUL4 associated factors
  • WD repeat domain containing
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000166500

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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