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PINX1 Antibody

PINX1 Antibody is available 1 time from Boster labs

PB9498 | PINX1 Antibody size: 0,1 mg | 442.55 USD

Catalog number PB9498
Supplier boster
Price 442.55 USD
Size 0,1 mg
1. Gene info
Identity 30046
Gene PINX1
Long gene name PIN2 (TERF1) interacting telomerase inhibitor 1
Synonyms gene name
  • PIN2/TERF1 interacting telomerase inhibitor 1
Synonyms
  • LPTL
  • LPTS
  • FLJ20565
  • MGC8850
  • Gno1
  • Pxr1
Synonyms name
  • PIN2 interacting protein 1
  • liver-related putative tumor suppressor
GenBank acession
  • AF418553
Locus 8p23.1
Discovery year 2010-04-26
Entrez gene record 54984
Pubmed identfication
  • 11003615
  • 11701125
RefSeq identity
  • NM_017884
Classification
  • G-patch domain containing
  • MicroRNA protein coding host genes
Target antigen PINX1
Clonality Polyclonal antibody
Clone Polyclonal antibody
Raised in rabbit
Type of the antibody IgG polyclonal antibody
Product form freeze-dried
Reacts with species: human, mouse, rat
Analyses WB
Immunogen A synthetic peptide corresponding to a sequence at the N-terminus of human PINX1 (54-83aa DHIKVQVKNNHLGLGATINNEDNWIAHQDD), different from the related mouse and rat sequences by three amino acids.
Product configuration Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purification Immunogen affinity purified.
Solubilization The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
Storage condtions Keep the PINX1 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
Tips The PINX1 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
Background PINX1, also known as PIN2 interacting protein 1, is a telomerase inhibitor and a possible tumor suppressor. It is mapped to 8p23. Over-expression of PINX1 results in decreased telomerase activity, telomere shortening, and induction of crisis. Reduction of PINX1 leads to an increase in telomerase activity and elongation of telomeres. PINX1 differs from other proteins that regulate telomere length in that it acts on telomerase while other proteins adjust telomere length without affecting telomerase activity. The PINX1 budding yeast orthologue Gnop1 inhibits telomerase by isolating the uncomplexed TERT protein so that it cannot associate with the telomerase template RNA, which prevents telomerase from being assembled. However, in humans, PINX1 impedes already assembled telomerase.
Related articles 1. Banik, S.S.R.; Counter, C.M. (September 2004). "Characterization of Interactions between PinX1 and Human Telomerase Subunits hTERT and hTR". Journal of Biological Chemistry. 2. Zhou, X Z; Lu K P (Nov 2001). "The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor". Cell (United States) 107 (3): 347–59.
Gene Name PINX1
Protein Name PIN2/TERF1-interacting telomerase inhibitor 1
Gene Full Name PIN2/TERF1 interacting, telomerase inhibitor 1
Synonyms 67-11-3 protein antibodyFLJ20565 antibody|Hepatocellular carcinoma-related putative tumor suppressor antibody|Liver-related putative tumor suppressor antibody|LPTL antibody|LPTS antibody|MGC8850 antibody|OTTHUMP00000224984 antibody|OTTHUMP00000224985 antibody| OTTHUMP00000224986 antibody|OTTHUMP00000225053 antibody|OTTHUMP00000225054 antibody|PIN2 interacting protein 1 antibody|Pin2-interacting protein X1 antibody|PIN2/TERF1-interacting telomerase inhibitor 1 antibody|PINX1 antibody|PINX1_HUMAN antibody|Protein 67-11-3 antibody|TRF1-interacting protein 1 antibody
Uniprot ID Q96BK5
Entrez GeneID 54984
Properties If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation anticorps
Gene targetPINX1
Short name PINX1 Antibody
Technique Antibody
Alternative name PINX1 (Antibody to)
Alternative technique antibodies
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PINX1 Antibody | Technique alternative | 01012615995
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