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Target antigen
DR3
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human, mouse, rat
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Analyses
WB
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Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human DR3(73-94aa CPQDTFLAWENHHNSECARCQA).
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the DR3 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The DR3 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
TNFRSF25(Tumor Necrosis Factor Receptor Superfamily Member 25), also known as LARD, APO3, DR3 or TNFR25, is a protein that in humans is encoded by the TNFRSF25 gene. Members of the mammalian tumor necrosis factor receptor(TNFR) family are cell-surface proteins that interact with a corresponding TNF-related ligand family. By fluorescence in situ hybridization, Marsters et al.(1996) mapped the Apo3 gene to 1p36.3. Marsters et al.(1996) showed that ectopic expression of Apo3 in mammalian cells triggered apoptosis and activated the transcription factor NF-kappa-B. They suggested that, like TNFR1, Apo3 may regulate distinct signaling pathways in different cellular contexts.
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Related articles
1. Borysenko, C. W., Furey, W. F., Blair, H. C. Comparative modeling of TNFRSF25 (DR3) predicts receptor destabilization by a mutation linked to rheumatoid arthritis. Biochem. Biophys. Res. Commun. 328: 794-799, 2005. 2. Fang, L., Adkins, B., Deyev, V., Podack, E. R. Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation. J. Exp. Med. 205: 1037-1048, 2008. 3. Marsters, S. A., Sheridan, J. P., Donahue, C. J., Pitti, R. M., Gray, C. L., Goddard, A. D., Bauer, K. D., Ashkenazi, A. Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa-B. Curr. Biol. 6: 1669-1676, 1996.
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Gene Name
TNFRSF25
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Protein Name
Tumor necrosis factor receptor superfamily member 25
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Gene Full Name
tumor necrosis factor receptor superfamily, member 25
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Synonyms
Apo 3 antibody|Apo-3 antibody|Apo3 antibody|Apoptosis inducing receptor AIR antibody|Apoptosis inducing receptor antibody|Apoptosis mediating receptor antibody|Apoptosis mediating receptor DR 3 antibody|Apoptosis mediating receptor DR3 antibody|Apoptosis mediating receptor TRAMP antibody|Apoptosis-inducing receptor AIR antibody|Apoptosis-mediating receptor DR3 antibody|Apoptosis-mediating receptor TRAMP antibody|DDR 3 antibody|DDR3 antibody|Death domain receptor 3 antibody|Death Receptor 3 antibody|Death receptor beta antibody|DR 3 antibody|LARD antibody|Lymphocyte associated receptor of death antibody|Lymphocyte-associated receptor of death antibody|Protein WSL antibody|Protein WSL-1 antibody|TNFRSF 12 antibody|TNFRSF 25 antibody|TNFRSF12 antibody|TNFRSF25 antibody|TNR25_HUMAN antibody|TR 3 antibody|TR3 antibody|TRAMP antibody|Translocating chain association membrane protein antibody|Tumor necrosis factor receptor superfamily member 12 antibody|Tumor necrosis factor receptor superfamily member 25 antibody|WSL 1 antibody|WSL antibody|WSL LR antibody|WSL protein antibody|WSL1 antibody|WSL1 protein antibody|WSLLR antibody
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Uniprot ID
Q93038
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
