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Synonyms
VMCM,TEK,Recombinant Human Tie2,hTIE2,p140 TEK,VMCM1,TIE-2,CD202b,Tie2
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Alternative_names
VMCM,TEK,Recombinant Human Tie2,hTIE2,p140 TEK,VMCM1,TIE-2,CD202b,Tie2
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Description
Human protein with His tag
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Recombinant
1
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Source
HEK 293 Cells
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Purity by SDS PAGE
≥ 97% by SDS-PAGE
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Molecular Weight
130-140 kDa
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Storage Temp
-20°C
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Shipping
Gel Pack
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Shelf Life
12 months
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Appearance
Sterile Filtered colorless solution
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Physical form description
Solid
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Reconstitution Instructions
Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.
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Background Information
TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Tie1 and Tie2 are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis, and hematopoiesis. Tie2 may play a role in a range of diseases with a vascular component, including neovascularization of tumors, psoriasis and inflammation. Mutations in the Tie2 gene are associated with dominantly inherited venous malformations (VMCM). Tie2 is required for normal angiogenesis and heart development during embryogenesis, and for post-natal hematopoiesis. Tie2 may activate or inhibit angiogenesis, depending on the context. Tie2 may have anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels.
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Amino acid sequence
The target protein is expressed with sequence (Ala23-Lys745) of human Tie2/CD202b/TEK
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Handling
Centrifuge the vial prior to opening.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional source
Recombinants or rec. proteins
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Group
recombinants
