Peroxiredoxin 2 Antibody (PRDX2)

• Catalog number
  R30932
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  Peroxiredoxin 2 (PRDX2)
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the Peroxiredoxin 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This Peroxiredoxin 2 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P32119
• Purity
  Antigen affinity
• Description
  Peroxiredoxin 2, also known as NKEFB, PRP, PRX2, PRXII or TPX1, is aproteinthat in humans is encoded by the PRDX2 gene. This gene encodes a member of a family of antioxidant enzymes which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The Prdx2-/- mice were healthy in appearance and fertile. Choi et al.(2005)demonstrated that PRDX2 is a negative regulator of PDGF signaling. Prx II deficiency results in increased production of peroxide, enhanced activation of PDGF receptor and phospholipase C-gamma-1, and subsequently increased cell proliferation and migration in response to PDGF. PRDX2 accounted for about half of the thioredoxin activity in parasite extracts, and expression was increased in the presence of chloroquine, regardless of P. falciparum strain susceptibility to the drug.
• Immunogen
  An amino acid sequence from the C-terminus of human PRDX2 (DTIKPNVDDSKEYFSKHN) was used as the immunogen for this Peroxiredoxin 2 antibody (100% homologous in human, mouse and rat).
• Storage
  After reconstitution, the Peroxiredoxin 2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Peroxiredoxin   PRDX2  
• Gene symbol
  PRDX2
• Short name
  Anti-Peroxiredoxin 2 (PRDX2)
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to Peroxiredoxin 2 (PRDX2)
• Alternative technique
  antibodies
• Alternative to gene target
  peroxiredoxin 2, HEL-S-2a and NKEF-B and NKEFB and PRP and PRX2 and PRXII and PTX1 and TDPX1 and TPX1 and TSA, PRDX2 and IDBG-31024 and ENSG00000167815 and 7001, peroxiredoxin activity, Cytoplasm, PRDX2 and IDBG-642937 and ENSBTAG00000012062 and 286793

Gene info

• Identity
  HGNC:9353
• Gene
  PRDX2
• Long gene name
  peroxiredoxin 2
• Synonyms gene
  • TDPX1
• Synonyms
  • PRP
  • NKEFB
  • TSA
  • PRXII
  • PRX2
  • MGC4104
• Synonyms name
  • thioredoxin-dependent peroxide reductase 1
  • thiol-specific antioxidant 1
  • natural killer-enhancing factor B
  • thioredoxin peroxidase 1
  • torin
• Locus
  19p13.13
• Discovery year
  1995-07-06
• Entrez gene record
  7001
• Pubmed identfication
  • 7607688
• RefSeq identity
  • NM_005809
• Classification
  • Peroxiredoxins
• VEGA ID
  OTTHUMG00000134285

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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