PINK1 - Blocking Peptide
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Catalog numberX2777B
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PricePlease ask
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Size50 μg
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CategoryProteins & Peptides
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Long descriptionThis peptide is the immunogen used to make Cat # X2762P. _x000B__x000B_Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6). A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.
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Antibody come fromThe antibody to SRalpha was raised against a recombinant protein corresponding to amino acids 39-295 which includes part of the amino terminal SRbeta binding region and the hinge region between it and the carboxyl-terminal GTPase domain.
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Other descriptionProvided as solution in phosphate buffered saline with 0.08% sodium azide.
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Clonenot specified
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Antigen antibody binding interactionPINK1 - Blocking Peptide
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Antibody is raised insee techfile
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Antibody s reacts withBlocking Peptide to Cat # X2762P
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Antibody s reacts with these speciesThis antibody doesn't cross react with other species
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Antibody s specificityNo Data Available
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ApplicationBlocking Peptide
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Antibody s suited forDetects SRalpha by Western blot analysis at 1 to 5 µg/ml. Also can be used to immunoprecipitate both subunits of SRP receptors under non-denaturing conditions. Optimal concentration should be evaluated by serial dilutions.
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Storage-20ºC
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Relevant references1. Moll, R., et al. The signal recognition particle receptor alpha subunit of the hyperthermophilic archaeon Acidianus ambivalens exhibits an intrinsic GTP-hydrolyzing activity. Biochim. Biophys. Acta 1997, 1335, 218-230._x000B__x000B_2. Young, J.C., et al. An amino-terminal domain containing hydrophobic and hydrophilic sequences binds the signal recognition particle receptor alpha subunit to the beta subunit on the endoplasmic reticulum membrane. J. Biol. Chem. 1995, 270, 15650-15657._x000B_
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Protein numbersee ncbi
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WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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TestYou can block the antibody by the specific target amino acid sequence of peptide.
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Propertiesblocking peptide
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DescriptionPeptides short amino acid chains or epitopes or blocking antagonists. The shortest peptides are dipeptides, consisting of 2 amino acids joined by a single peptide bond, followed by tripeptides, tetra peptides, ... till polypeptides that are long, continuous, and unbranched synthetic peptide chains. These biological oligomers and polymers can be Solid-phase peptide synthesis (SPPS), or in continue produced for custom peptide synthesis projects. The High-efficiency solid phase peptide synthesis (HE-SPPS) is give very low production costs.
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Gene target
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Gene symbolPINK1-AS, PINK1
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Short namePINK1 - Blocking Peptide
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Techniqueblocking peptide, Blocking, peptide, blocking peptides, nordc made this blocking amino acid sequence or peptide to block the gene target in a volume of 1. For western blot it is often requested to block your antibody and to see the band of the analyzed protein disappear. This is called a negative control by blocking the WB antibody. peptides
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Isotypenot specified
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Labelunlabeled
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Alternative namephosphatase and tensin homolog induced putative kinase 1 - inhibiting short protein sequence
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Alternative techniquecontrol, peptides
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Alternative to gene targetPTEN induced putative kinase 1, PINK1 and IDBG-92922 and ENSG00000158828 and 65018, transferase activity, nuclei, Pink1 and IDBG-199773 and ENSMUSG00000028756 and 68943, PINK1 and IDBG-645657 and ENSBTAG00000006084 and 510683
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Gene info
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Identity
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Gene
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Long gene namePINK1 antisense RNA
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Synonyms gene
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Synonyms gene name
- PINK1 antisense RNA 1 (non-protein coding)
- PINK1 antisense RNA (non-protein coding)
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Synonyms
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GenBank acession
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Locus
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Discovery year2010-08-19
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Pubmed identfication
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Classification
- Antisense RNAs
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namePTEN induced kinase 1
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Synonyms gene
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Synonyms gene name
- Parkinson disease (autosomal recessive) 6
- PTEN induced putative kinase 1
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-02-08
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MicroRNA protein coding host genes
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VEGA ID
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Locus Specific Databases