Erlotinib, Hydrochloride Salt

Alternative_name

CP-358774, OSI-775
Description

Erlotinib is an inhibitor of human Epidermal growth factor receptor (EGFR) tyrosine kinase (IC₅₀ = 2 nM) and decreases EGFR autophosphorylation in tumor cells (IC₅₀ = 20 nM). Studies in cell lines and enzyme assays have both shown that erlotinib inhibits EGFR at concentrations significantly lower than those needed to inhibit c-src and v-abl.
CAS Number

183319-69-9
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₂H₂₃N₃O₄.HCl
Molecular Weight

429.9
Cell Permeable

Yes
Purity

≥99% by HPLC
Solubilities

DMSO
Handling

Protect from light and moisture
Tag Line

An EGFR kinase inhibitor
Storage Condition

-20°C
Shipping Condition

RT
Shelf Life

24months
MDL Number

MFCD07781272
PubChem CID

176871
PubChem CID Link
SMILES

COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC.Cl
InChi

InChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8- 26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3, (H,23,24,25);1H
InChi Key

GTTBEUCJPZQMDZ-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes