Erlotinib, Hydrochloride Salt
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Catalog number
1588-1000
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Price
Please ask
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Size
1 g
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Alternative_name
CP-358774, OSI-775
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Description
Erlotinib is an inhibitor of human Epidermal growth factor receptor (EGFR) tyrosine kinase (IC₅₀ = 2 nM) and decreases EGFR autophosphorylation in tumor cells (IC₅₀ = 20 nM). Studies in cell lines and enzyme assays have both shown that erlotinib inhibits EGFR at concentrations significantly lower than those needed to inhibit c-src and v-abl.
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CAS Number
183319-69-9
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₂H₂₃N₃O₄.HCl
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Molecular Weight
429.9
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Cell Permeable
Yes
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Purity
≥99% by HPLC
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Solubilities
DMSO
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Handling
Protect from light and moisture
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Tag Line
An EGFR kinase inhibitor
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Storage Condition
-20°C
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Shipping Condition
RT
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Shelf Life
24months
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MDL Number
MFCD07781272
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PubChem CID
176871
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SMILES
COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC.Cl
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InChi
InChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8- 26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3, (H,23,24,25);1H
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InChi Key
GTTBEUCJPZQMDZ-UHFFFAOYSA-N
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MSDS Available
Yes
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Gene target
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Short name
Erlotinib, Hydrochloride Salt
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Alternative name
Erlotinib, Hydrochloride Salt
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Product images
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