PD-123319 ditrifluoroacetate

Alternative_name

1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid ditrifluoroacetate
Description

PD-123319 is a potent, selective, non-peptide angiotensin AT2 receptor antagonist (IC₅₀ values are 34 and 210 nM in rat adrenal tissue and brain respectively). It has been used to selectively examine the specific roles for AT1R and AT2R in hypertensive and other vascular research-related models.
CAS Number

130663-39-7
Structure Available

Yes
Salt Form

No
Molecular Formula

C₃₁H₃₂N₄O₃.2CF₃CO₂H
Molecular Weight

736.67
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

H₂O (>70 mg/ml)
Handling

Protect from air and light
Tag Line

A potent, selective, non-peptide angiotensin AT2 receptor antagonist
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD11046022
SMILES

O=C(C1CC2=C(N=CN2CC3=CC=C(N(C)C)C(C)=C3)CN1C(C(C4=CC=CC=C4)C5=CC=CC=C5)=O)O.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
InChi

InChI=1S/C31H32N4O3.2C2HF3O2/c1-21-16-22(14-15-26(21)33(2)3)18-34-20-32-25-19-35(28(31(37)38)17-27(25)34)30(36)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24;2*3-2(4,5)1(6)7/h4-16,20,28-29H,17-19H2,1-3H3,(H,37,38);2*(H,6,7)
InChi Key

GPKQIEZLHVGJQH-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:3358
Gene

ENPP3
Long gene name

ectonucleotide pyrophosphatase/phosphodiesterase 3
Synonyms gene
- PDNP3
Synonyms
- PD-IBETA
- gp130RB13-6
- B10
- CD203c
GenBank acession
- AF005632
Locus

6q23.2
Discovery year

1995-08-10
Entrez gene record

5169
Pubmed identfication
- 9344668
Classification
- Ectonucleotide pyrophosphatase/phosphodiesterase family
- CD molecules
VEGA ID

OTTHUMG00000016292

Identity

HGNC:18731
Gene

PDCD1LG2
Long gene name

programmed cell death 1 ligand 2
Synonyms
- PD-L2
- Btdc
- PDL2
- bA574F11.2
- CD273
- B7-DC
Synonyms name
- B7 dendritic cell molecule
GenBank acession
- AF344424
Locus

9p24.1
Discovery year

2003-11-14
Entrez gene record

80380
Pubmed identfication
- 11224527
RefSeq identity
- NM_025239
Classification
- B7 family
- CD molecules
- Immunoglobulin like domain containing
- Receptor ligands
VEGA ID

OTTHUMG00000019504