Target of this antibody:
Alternative names of antibody target:
Cysteine rich transmembrane BMP regulator 1 (chordin-like), CRIM-1, Cysteine-rich motor neuron 1 protein, Cysteine-rich repeat-containing protein S52
CRIM1 (cysteine-rich motor neuron 1), a glycosylated type I transmembrane protein, plays a role in tissue development i.e. capillary formation and maintenance during angiogenesis. It contains an N-terminal IGF-binding protein-like motif and six von Willebrand-like cysteine-rich repeats (CRRs) in its extracellular domain. CRIM1 interacts with BMP4 and BMP7 via the CRRs and functions as an antagonist. CRIM1 is developmentally expressed in a number of tissues including the pancreas, kidney, placenta, brain and blood vessels. CRIM1 may participate in CNS and placental development by interacting with growth factors involved in motor neuron differentiation and survival.
Clonality of antibody:
This antibody reacts with:
CRIM1 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human Crim1.
Concentration of antibody:
Form of antibody:
Formulation of this antibody:
100 µg (1 mg/ml) in 1X PBS containing 0.02 % sodium azide.
Affinity chromatography purified via peptide column
This antibody has been succesfully tested for use in following methods:
Western blot, ELISA
Western Blot: 1 - 2 μg/ml, ELISA. However, the optimal conditions should be determined individually.
Shelf time: 12 months in temp.: -20 deg.C
How to handle this antibody:
The antibody solution should be gently mixed before use.
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.