BAY 43-9006, Free base
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Catalog number2142-100
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PricePlease ask
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Size100 mg
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Alternative_nameSorafenib
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DescriptionA free base form of BAY 43-9006 (Sorafenib) (Cat. No. 1594-25,100). Acts as an inhibitor of Raf-1 and B-Raf (IC₅₀ = 6 and 22 nM, respectively), as well as several receptor tyrosine kinases, including VEGFR2, VEGFR3, PDGFRβ, FLT3, and c-Kit (IC₅₀ = 90, 15, 20, 57, and 58 nM, respectively. It poorly inhibits ERK1, MEK1, and several other kinases (IC₅₀ = >10 μM).
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CAS Number284461-73-0
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₁H₁₆ClF₃N₄O₃
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Molecular Weight464.82
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Cell PermeableYes
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Purity≥99% by HPLC
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SolubilitiesDMSO (200 mg/ml)
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HandlingProtect from air and light
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Tag LineA Raf kinase inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life24months
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MDL NumberMFCD06411450
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PubChem CID216239
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SMILESCNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
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InChi KeyMLDQJTXFUGDVEO-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolIGLV7-43, IGHVII-43-1, SNORD115-43, IGHV3-43, IGKV1D-43, RNU6-43P, SNORD17, TARDBP, CCZ1, RLIM
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Short nameBAY 43-9006, Free base
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Alternative nameBAY 43-9006, Free base
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Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin lambda variable 7-43
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GenBank acession
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Locus
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Discovery year2000-05-08
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin lambda locus at 22q11.2
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin heavy variable (II)-43-1 (pseudogene)
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Synonyms gene name
- immunoglobulin heavy variable (II)-43-1
- immunoglobulin heavy variable (II)-43-1 pseudogene
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-17
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin heavy locus at 14q32.33
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, C/D box 115-43
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Synonyms
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GenBank acession
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Locus
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Discovery year2007-02-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNAs, C/D box
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin heavy variable 3-43
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GenBank acession
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Locus
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Discovery year2000-04-04
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin heavy locus at 14q32.33
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin kappa variable 1D-43
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GenBank acession
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Locus
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Discovery year2000-04-18
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin kappa locus at 2p11.2
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameRNA, U6 small nuclear 43, pseudogene
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Synonyms gene
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Synonyms gene name
- RNA, U6 small nuclear 43
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Locus
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Discovery year2008-06-10
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Entrez gene record
Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, C/D box 17
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Synonyms
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Locus
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Discovery year2006-05-02
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNAs, C/D box
Gene info
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Identity
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Gene
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Long gene nameTAR DNA binding protein
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-01-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- RNA binding motif containing
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameCCZ1 homolog, vacuolar protein trafficking and biogenesis associated
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Synonyms gene
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Synonyms gene name
- chromosome 7 open reading frame 28A
- CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
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Synonyms
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GenBank acession
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Locus
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Discovery year2003-07-14
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namering finger protein, LIM domain interacting
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Synonyms gene
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Synonyms gene name
- ring finger protein 12
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2002-04-30
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Ring finger proteins
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VEGA ID
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Locus Specific Databases