RIG-I Antibody (DDX58)

• Catalog number
  F46992-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  RIG-I (DDX58)
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the DDX58 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This DDX58 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  O95786
• Purity
  Purified
• Description
  DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. RIG-I contains RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, RIG-I/DDX58 triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). This protein is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV.
• Immunogen
  A portion of amino acids 585-614 from the human protein was used as the immunogen for this DDX58 antibody.
• Storage
  Aliquot the DDX58 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  RIG-I   DDX58  
• Gene symbol
  DDX58, DKK3, FABP6, RPS15, DIRAS1, TANK, FABP2, PSMB2, CPLX1
• Short name
  Anti-RIG-I (DDX58)
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to RIG-I (DDX58)
• Alternative technique
  antibodies
• Alternative to gene target
  DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, RIG-I and RIGI and RLR-1, DDX58 and IDBG-55854 and ENSG00000107201 and 23586, hydrolase activity, Cell surfaces, Ddx58 and IDBG-135957 and ENSMUSG00000040296 and 230073, DDX58 and IDBG-629773 and ENSBTAG00000003366 and 504760

Gene info

• Identity
  HGNC:19102
• Gene
  DDX58
• Long gene name
  DExD/H-box helicase 58
• Synonyms gene name
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
• Synonyms
  • RIG-I
  • FLJ13599
  • DKFZp434J1111
  • RIG-1
  • RIG1
• Synonyms name
  • RNA helicase RIG-I
  • retinoic acid inducible gene I
• GenBank acession
  • AF038963
• Locus
  9p21.1
• Discovery year
  2004-05-10
• Entrez gene record
  23586
• Pubmed identfication
  • 21690088
• RefSeq identity
  • NM_014314
• Classification
  • DEAD-box helicases
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000019746

Gene info

• Identity
  HGNC:2893
• Gene
  DKK3
• Long gene name
  dickkopf WNT signaling pathway inhibitor 3
• Synonyms gene name
  • dickkopf (Xenopus laevis) homolog 3
  • dickkopf 3 homolog (Xenopus laevis)
• Synonyms
  • REIC
  • RIG
• Synonyms name
  • regulated in glioma
• GenBank acession
  • AF177396
• Locus
  11p15.3
• Discovery year
  2000-09-01
• Entrez gene record
  27122
• Pubmed identfication
  • 10570958
• RefSeq identity
  • NM_013253
• VEGA ID
  OTTHUMG00000165709

Gene info

• Identity
  HGNC:3561
• Gene
  FABP6
• Long gene name
  fatty acid binding protein 6
• Synonyms gene name
  • fatty acid binding protein 6, ileal
• Synonyms
  • I-15P
  • ILLBP
  • I-BAP
  • ILBP3
  • I-BABP
  • ILBP
  • I-BALB
• Synonyms name
  • illeal lipid-binding protein
  • ileal bile acid binding protein
  • gastrotropin
• GenBank acession
  • U19869
• Locus
  5q33.3
• Discovery year
  1997-09-12
• Entrez gene record
  2172
• Pubmed identfication
  • 7894165
  • 7619861
• RefSeq identity
  • NM_001040442
• Classification
  • Fatty acid binding protein family
• VEGA ID
  OTTHUMG00000130329

Gene info

• Identity
  HGNC:10388
• Gene
  RPS15
• Long gene name
  ribosomal protein S15
• Synonyms
  • RIG
  • MGC111130
  • S15
• Synonyms name
  • 40S ribosomal protein S15
  • homolog of rat insulinoma
  • insulinoma protein
• Locus
  19p13.3
• Discovery year
  1992-04-16
• Entrez gene record
  6209
• Pubmed identfication
  • 2159154
• RefSeq identity
  • NM_001018
• Classification
  • S ribosomal proteins
• VEGA ID
  OTTHUMG00000140099

Gene info

• Identity
  HGNC:19127
• Gene
  DIRAS1
• Long gene name
  DIRAS family GTPase 1
• Synonyms gene name
  • DIRAS family, GTP-binding RAS-like 1
• Synonyms
  • Di-Ras1
  • GBTS1
  • RIG
• Synonyms name
  • Ras-related inhibitor of cell growth
  • small GTP-binding tumor suppressor 1
  • distinct subgroup of the Ras family member 1
• GenBank acession
  • BC030660
• Locus
  19p13.3
• Discovery year
  2003-02-07
• Entrez gene record
  148252
• Pubmed identfication
  • 12107278
  • 12194967
• Classification
  • RAS type GTPase family
• VEGA ID
  OTTHUMG00000180439

Gene info

• Identity
  HGNC:11562
• Gene
  TANK
• Long gene name
  TRAF family member associated NFKB activator
• Synonyms gene
  • TRAF2
• Synonyms gene name
  • TRAF family member-associated NFKB activator
• Synonyms
  • I-TRAF
• GenBank acession
  • U59863
• Locus
  2q24.2
• Discovery year
  1997-06-12
• Entrez gene record
  10010
• Pubmed identfication
  • 8710854
  • 8855313
• RefSeq identity
  • NM_133484
• VEGA ID
  OTTHUMG00000132037

Gene info

• Identity
  HGNC:3556
• Gene
  FABP2
• Long gene name
  fatty acid binding protein 2
• Synonyms gene name
  • fatty acid binding protein 2, intestinal
• Synonyms
  • I-FABP
• GenBank acession
  • J03465
• Locus
  4q26
• Discovery year
  1986-01-01
• Entrez gene record
  2169
• RefSeq identity
  • NM_000134
• Classification
  • Fatty acid binding protein family
• VEGA ID
  OTTHUMG00000132972

Gene info

• Identity
  HGNC:9539
• Gene
  PSMB2
• Long gene name
  proteasome 20S subunit beta 2
• Synonyms gene name
  • proteasome (prosome, macropain) subunit, beta type, 2
  • proteasome subunit beta 2
• Synonyms
  • HC7-I
• Synonyms name
  • proteasome subunit β4
• GenBank acession
  • D26599
• Locus
  1p34.3
• Discovery year
  1995-05-03
• Entrez gene record
  5690
• Pubmed identfication
  • 7918633
• RefSeq identity
  • NM_002794
• Classification
  • Proteasome
• VEGA ID
  OTTHUMG00000004169

Gene info

• Identity
  HGNC:2309
• Gene
  CPLX1
• Long gene name
  complexin 1
• Synonyms
  • CPX-I
• GenBank acession
  • AF022383
• Locus
  4p16.3
• Discovery year
  1999-09-09
• Entrez gene record
  10815
• Pubmed identfication
  • 7553862
• VEGA ID
  OTTHUMG00000160005

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products