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CDCA8 Antibody ALEXA FLUOR

CDCA8 Antibody ALEXA FLUOR is available 5 times from Bioss primary conjugated antibodies. alexa fluor labs

bs-7834R-A350 | CDCA8 Antibody, ALEXA FLUOR 350 size: 100ul | 383.66 USD

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bs-7834R-A488 | CDCA8 Antibody, ALEXA FLUOR 488 size: 100ul | 383.66 USD

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bs-7834R-A555 | CDCA8 Antibody, ALEXA FLUOR 555 size: 100ul | 383.66 USD

Long name CDCA8 Polyclonal Antibody, ALEXA FLUOR 555 Conjugated
Also known as Anti-CDCA8 PAb ALEXA FLUOR 555
Conjugated with ALEXA FLUOR® 555
Excitation emission 553nm/568nm
Properties For facs or microscopy Alexa 1 conjugate.Very high photo stable ALEXA conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Conjugation Alexa Fluor,ALEXA FLUOR 555
French translation anticorps
Label ALEXA FLUOR 555
Alternative name CDCA8 (Antibody to), ALEXA FLUOR 555
1. Gene info
Identity14629
GeneCDCA8
Long gene name cell division cycle associated 8
Synonyms name
GenBank acession
Locus1p34.3
Discovery year 2002-04-03
Entrez gene record55143
Pubmed identfication
RefSeq identity
Classification
  • Chromosomal passenger complex
Havana BLAST/BLATOTTHUMG00000004320
MeSH Data
Concept
Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
Additional information
PubMedThese findings reveal a previously unrecognized but direct link between HP1 and CPC localization in the centromere and illustrate the critical role of borealin-HP1 interaction in orchestrating an accurate cell division.
A functional module within the chromosomal passenger complex involving the inner centromere protein INCENP, Survivin, and Borealin.
It is recorded that borealin is a cell cycle regulator, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues.
AURKB phosphorylates CHMP4C at 3 serines its C-terminal tail.Phosphorylation at these sites appears essential for CHMP4C function because their mutation leads to cytokinesis defects.
enhanced CDCA8 promoter activities by NF-Y overexpression and reduced CDCA8 transcription by NF-Y knockdown further verified that NF-Y is a positive regulator of CDCA8 transcription.
Data describe a mitotic SUMO2/3 conjugation-deconjugation cycle of Borealin and further assign a regulatory function of RanBP2 and SENP3 in the mitotic SUMO pathway.
Disrupting AurKB before mitotic entry reduces chromosomal passenger complex (CPC) localization to the centromere. AurKB plays a minimal role in maintaining CPC localization once cells are in mitosis.
Borealin is phosphorylated during mitosis. Neither residue S165, T106 nor phosphorylation of borealin by Aurora B Kinase is required to generate the mitotic, shifted form of Borealin.
Suppression of CDCA8 expression with small interfering RNA against CDCA8 significantly suppressed the growth of lung cancer cells.
In colorectal cancer patients, Borealin expression was positively correlated with age, lymph node metastasis and neoplasm staging.
Gene ontology - Molecular functionprotein binding
Product images
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bs-7834R-A594 | CDCA8 Antibody, ALEXA FLUOR 594 size: 100ul | 383.66 USD

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bs-7834R-A647 | CDCA8 Antibody, ALEXA FLUOR 647 size: 100ul | 383.66 USD

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Modification Unmodified
Clonality Polyclonal
Category Conjugated Primary Antibodies
Host Organism Rabbit (Oryctolagus cuniculus)
Source This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Borealin/CDCA8
Specificity This is a highly specific antibody against CDCA8.
Tested applications IF(IHC-P)
Clone Polyclonal antibody
Modification Site None
Synonyms BOR; BOREA_HUMAN; Borealin; CDCA8; Cell division cycle associated 8; Cell division cycle-associated protein 8; Dasra B; Dasra-B; DasraB; FLJ10468; FLJ12042; hDasra-B; MESRGP; OTTHUMP00000004514; Pluripotent embryonic stem cell-related gene 3 protein.
Purification Purified by Protein A.
Crossreactivity Human, Mouse, Rat
Gene ID Number 55143
Recommended dilutions IF(IHC-P)(1:50-200)
Background of the antigen Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
Concentration 1ug per 1ul
Target Antigen CDCA8
Storage conditions Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Cross-reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Gene targetCDCA8
Short name CDCA8 Antibody,
Technique Antibody
Alternative technique antibodies
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