Anti-FIG4/SAC3 (Polyclonal), ALEXA Fluor 594

• Catalog number
  GENTObs-11690R-A594
• Price
  Please ask
• Size
  100 microliters

• Type
  Conjugated Primary Antibody
• Conjugated with
  ALEXA FLUOR® 594
• Host organism
  Rabbit (Oryctolagus cuniculus)
• Target Protein Peptide
  FIG4/SAC3
• Specificity
  This antibody reacts specifically with FIG4/SAC3
• Modification
  No modification has been applied to this antibody
• Modification site
  None
• Clonality
  Polyclonal Antibody
• Clone
  Polyclonal Antibodies
• Concentration
  1ug per 1ul
• Subcellular locations
  N/A
• Antigen Source
  KLH conjugated synthetic peptide derived from human FIG4
• Gene ID
  N/A
• Swiss Prot
  N/A
• Applications
  IF(IHC-P)
• Applications with corresponding dilutions
  IF(IHC-P)(1:50-200)
• Cross reactive species
  Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
• Cross Reactive Species details
  No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
• Background information
  FIG4 is a 907 amino acid protein that contains one SAC domain through which it is thought to function as a phosphoinositide phosphatase that may play an important role in signal transduction and vesicle trafficking. Defects in the gene encoding FIG4 are the cause of Charcot-Marie-Tooth disease type 4J (CMT4J) and amyotrophic lateral sclerosis type 11 (ALS11), both of which negatively affect the nervous system. CMT4J is a recessive demyelinating disorder of the peripheral nervous system and is characterized by reduced motor nerve conduction velocities and axonal degeneration. Unlike CMT4J, ALS11 is characterized by the degeneration of upper motor neurons in the brain and lower neurons in the spinal cord, causing paralysis and, ultimately, death.
• Purification method
  Purified by Protein A.
• Storage
  Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
• Excitation emission
  590nm/617nm
• Synonyms
  5-bisphosphate 5-phosphatase; Fig4; FIG4_HUMAN; KIAA0274; ALS11; Phosphatidylinositol 3; hSac3; Phosphatidylinositol 3,5 bisphosphate 5 phosphatase; Polyphosphoinositide phosphatase; SAC domain containing protein 3; SAC domain-containing protein 3; SAC3.
• Also known as
  FIG4/SAC3 Polyclonal Antibody
• Other name
  Anti-FIG4/SAC3 Polyclonal
• Advisory
  Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
• Properties
  For facs or microscopy Alexa 1 conjugate.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

• Gene target
  FIG4/SAC3  
• Gene symbol
  FIG4, MCM3AP
• Short name
  Anti-FIG4/SAC3
• Technique
  Polyclonal, anti-, anti, antibody to, antibodies, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  FIG4/SAC3 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:16873
• Gene
  FIG4
• Long gene name
  FIG4 phosphoinositide 5-phosphatase
• Synonyms gene
  • KIAA0274
• Synonyms gene name
  • KIAA0274
  • FIG4 homolog (S. cerevisiae)
  • FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)
• Synonyms
  • SAC3
  • hSac3
  • dJ249I4.1
  • ALS11
  • CMT4J
• GenBank acession
  • D87464
• Locus
  6q21
• Discovery year
  2003-11-26
• Entrez gene record
  9896
• Pubmed identfication
  • 9039502
  • 11274189
  • 17572665
• RefSeq identity
  • NM_014845
• Classification
  • Phosphoinositide phosphatases
• VEGA ID
  OTTHUMG00000015352
• Locus Specific Databases
  • LRG_241

Gene info

• Identity
  HGNC:6946
• Gene
  MCM3AP
• Long gene name
  minichromosome maintenance complex component 3 associated protein
• Synonyms gene name
  • minichromosome maintenance deficient (S. cerevisiae) 3-associated protein
  • MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein
• Synonyms
  • Map80
  • KIAA0572
  • GANP
  • SAC3
• Synonyms name
  • germinal-centre associated nuclear protein
• GenBank acession
  • AB005543
• Locus
  21q22.3
• Discovery year
  1999-03-04
• Entrez gene record
  8888
• Pubmed identfication
  • 9712829
  • 16914116
  • 21195085
• RefSeq identity
  • NM_003906
• Classification
  • Lysine acetyltransferases
  • Transcription and export complex 2
• VEGA ID
  OTTHUMG00000090630

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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